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Literature summary extracted from

  • Coleman, C.N.; Stoller, R.G.; Drake, J.C.; Chabner, B.A.
    Deoxycytidine kinase: properties of the enzyme from human leukemic granulocytes (1975), Blood, 46, 791-803.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.74 Cytosine arabinoside triphosphate weak Homo sapiens
2.7.1.74 dCTP cytosine arabinoside as substrate Homo sapiens
2.7.1.74 deoxycytidine cytosine arabinoside as substrate Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.74 0.0033 0.0093 deoxycytidine
-
Homo sapiens
2.7.1.74 0.02 0.04 cytosine arabinoside D-isomer Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.74 68000
-
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.74 partial Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 leukemia cell from acute myeloid leukemia (AML) patients Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 ATP + 2'-deoxycytidine
-
Homo sapiens ADP + 5'-dCMP
-
?
2.7.1.74 GTP + 2'-deoxycytidine
-
Homo sapiens GDP + 2'-deoxy-CMP
-
?
2.7.1.74 NTP + cytosine arabinoside
-
Homo sapiens NDP + cytosine arabinoside 5'-monophosphate
-
?
2.7.1.74 NTP + deoxycytidine
-
Homo sapiens NDP + dCMP
-
?