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Literature summary extracted from

  • Vogel, S.; Hoppe, J.
    Polyamines stimulate the phosphorylation of phosphatidylinositol in membranes from A431 cells (1986), Eur. J. Biochem., 154, 253-257.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.67 histone stimulates Homo sapiens
2.7.1.67 phosvitin stimulates Homo sapiens
2.7.1.67 poly(L-lysine) stimulates Homo sapiens
2.7.1.67 Polyarginine stimulates Homo sapiens
2.7.1.67 spermidine half-maximal stimulation at 1.5 mM Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.67 2'-dATP
-
 Homo sapiens
2.7.1.67 3'-dATP
-
 Homo sapiens
2.7.1.67 8-bromo-ATP
-
 Homo sapiens
2.7.1.67 adenosine
-
 Homo sapiens
2.7.1.67 ADP
-
 Homo sapiens
2.7.1.67 AMP
-
 Homo sapiens
2.7.1.67 cAMP
-
 Homo sapiens
2.7.1.67 GTP
-
 Homo sapiens
2.7.1.67 N6-dimethylamine-adenosine 5'-triphosphate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.67 0.02
-
 ATP pH 7.4, 25°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.67 membrane
-
 Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.67 A-431 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.67 0.01
-
 ADP pH 7.4, 25°C, in absence of spermidine Homo sapiens
2.7.1.67 0.012
-
 3'-dATP pH 7.4, 25°C, in absence of spermidine Homo sapiens
2.7.1.67 0.013
-
 GTP pH 7.4, 25°C, in absence of spermidine Homo sapiens
2.7.1.67 0.014
-
 2'-dATP pH 7.4, 25°C, in presence of 3 mM spermidine Homo sapiens
2.7.1.67 0.04
-
 N6-dimethylamine-adenosine 5'-triphosphate pH 7.4, 25°C, in presence of 3 mM spermidine Homo sapiens
2.7.1.67 0.07
-
 adenosine pH 7.4, 25°C, in absence of spermidine Homo sapiens
2.7.1.67 0.11
-
 8-bromo-ATP pH 7.4, 25°C, in presence of 3 mM spermidine Homo sapiens
2.7.1.67 0.5
-
 cAMP pH 7.4, 25°C, in absence of spermidine Homo sapiens
2.7.1.67 0.53
-
 AMP pH 7.4, 25°C, in absence of spermidine Homo sapiens
2.7.1.67 1.9
-
 N6-dimethylamine-adenosine 5'-triphosphate pH 7.4, 25°C, in absence of spermidine Homo sapiens