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Literature summary extracted from

  • Phillips, N.F.B.; Hsieh, P.C.; Kowalczyk, T.H.
    Polyphosphate glucokinase (1999), Prog. Mol. Subcell. Biol., 23, 101-125.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.63 expression in Escherichia coli Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.63 0.000005
-
 (phosphate)400
-
 Propionibacterium freudenreichii subsp. shermanii
2.7.1.63 0.00008
-
 (phosphate)400
-
 Mycobacterium tuberculosis
2.7.1.63 0.0012
-
 (phosphate)35
-
 Propionibacterium freudenreichii subsp. shermanii
2.7.1.63 0.0046
-
 (phosphate)35
-
 Mycobacterium tuberculosis
2.7.1.63 0.0088
-
 (phosphate)35
-
 Acidipropionibacterium acidipropionici
2.7.1.63 0.037
-
 (phosphate)400
-
 Acidipropionibacterium acidipropionici
2.7.1.63 0.15
-
 ATP
-
 Propionibacterium freudenreichii subsp. shermanii
2.7.1.63 0.4
-
 ATP
-
 Acidipropionibacterium acidipropionici
2.7.1.63 0.88
-
 ATP
-
 Mycobacterium tuberculosis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.63 30000
-
 2 * 30000, about, SDS-PAGE Propionibacterium freudenreichii subsp. shermanii
2.7.1.63 30000
-
 2 * 30000, about, SDS-PAGE Mycobacterium tuberculosis
2.7.1.63 30000
-
 2 * 30000, about, SDS-PAGE Acidipropionibacterium acidipropionici
2.7.1.63 63000
-
 gel filtration Propionibacterium freudenreichii subsp. shermanii
2.7.1.63 66000
-
 gel filtration Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.63 (phosphate)n + D-glucose Propionibacterium freudenreichii subsp. shermanii constitutive enzyme, enzyme is involved in metabolism of glucose (phosphate)n-1 + D-glucose 6-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.63 Acidipropionibacterium acidipropionici
-
-
-
2.7.1.63 Corynebacterium xerosis
-
-
-
2.7.1.63 Mycobacterium tuberculosis
-
-
-
2.7.1.63 Mycolicibacterium phlei
-
-
-
2.7.1.63 Nocardia minima
-
-
-
2.7.1.63 Propionibacterium freudenreichii subsp. shermanii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.63 (phosphate)35 + D-glucose
-
 Propionibacterium freudenreichii subsp. shermanii (phosphate)34 + D-glucose 6-phosphate
-
 ?
2.7.1.63 (phosphate)35 + D-glucose
-
 Mycobacterium tuberculosis (phosphate)34 + D-glucose 6-phosphate
-
 ?
2.7.1.63 (phosphate)35 + D-glucose
-
 Acidipropionibacterium acidipropionici (phosphate)34 + D-glucose 6-phosphate
-
 ?
2.7.1.63 (phosphate)400 + D-glucose
-
 Propionibacterium freudenreichii subsp. shermanii (phosphate)399 + D-glucose 6-phosphate
-
 ?
2.7.1.63 (phosphate)400 + D-glucose
-
 Mycobacterium tuberculosis (phosphate)399 + D-glucose 6-phosphate
-
 ?
2.7.1.63 (phosphate)400 + D-glucose
-
 Acidipropionibacterium acidipropionici (phosphate)399 + D-glucose 6-phosphate
-
 ?
2.7.1.63 (phosphate)n + D-glucose constitutive enzyme, enzyme is involved in metabolism of glucose Propionibacterium freudenreichii subsp. shermanii (phosphate)n-1 + D-glucose 6-phosphate
-
 ?
2.7.1.63 ATP + D-glucose
-
 Propionibacterium freudenreichii subsp. shermanii ADP + D-glucose 6-phosphate
-
 ?
2.7.1.63 ATP + D-glucose
-
 Mycobacterium tuberculosis ADP + D-glucose 6-phosphate
-
 ?
2.7.1.63 ATP + D-glucose
-
 Nocardia minima ADP + D-glucose 6-phosphate
-
 ?
2.7.1.63 CTP + glucose
-
 Propionibacterium freudenreichii subsp. shermanii CDP + D-glucose 6-phosphate
-
 ?
2.7.1.63 CTP + glucose
-
 Mycobacterium tuberculosis CDP + D-glucose 6-phosphate
-
 ?
2.7.1.63 GTP + glucose
-
 Propionibacterium freudenreichii subsp. shermanii GDP + D-glucose 6-phosphate
-
 ?
2.7.1.63 GTP + glucose
-
 Mycobacterium tuberculosis GDP + D-glucose 6-phosphate
-
 ?
2.7.1.63 TTP + glucose
-
 Mycobacterium tuberculosis TDP + D-glucose 6-phosphate
-
 ?
2.7.1.63 UTP + glucose
-
 Propionibacterium freudenreichii subsp. shermanii UDP + D-glucose 6-phosphate
-
 ?
2.7.1.63 UTP + glucose
-
 Mycobacterium tuberculosis UDP + D-glucose 6-phosphate
-
 ?
2.7.1.63 XTP + glucose
-
 Mycobacterium tuberculosis XDP + D-glucose 6-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.63 dimer 2 * 30000, about, SDS-PAGE Propionibacterium freudenreichii subsp. shermanii
2.7.1.63 dimer 2 * 30000, about, SDS-PAGE Mycobacterium tuberculosis
2.7.1.63 dimer 2 * 30000, about, SDS-PAGE Acidipropionibacterium acidipropionici

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.1.63 25
-
 ATP
-
 Propionibacterium freudenreichii subsp. shermanii
2.7.1.63 41
-
 (phosphate)400
-
 Acidipropionibacterium acidipropionici
2.7.1.63 55
-
 (phosphate)35
-
 Acidipropionibacterium acidipropionici
2.7.1.63 57
-
 (phosphate)35
-
 Propionibacterium freudenreichii subsp. shermanii
2.7.1.63 63
-
 ATP
-
 Acidipropionibacterium acidipropionici
2.7.1.63 116
-
 glucose
-
 Mycobacterium tuberculosis
2.7.1.63 163
-
 (phosphate)400
-
 Mycobacterium tuberculosis
2.7.1.63 196
-
 (phosphate)35
-
 Mycobacterium tuberculosis
2.7.1.63 371
-
 (phosphate)400
-
 Propionibacterium freudenreichii subsp. shermanii