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Literature summary extracted from

  • Schulte, A.E.; van der Heijden, R.; Verpoorte, R.
    Purification and characterization of mevalonate kinase from suspension-cultured cells of Catharanthus roseus (L.) G. Don (2000), Arch. Biochem. Biophys., 378, 287-298.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.36 ADP product inhibition vs. ATP at concentration above 2 mM Catharanthus roseus
2.7.1.36 farnesyl diphosphate competitive vs. ATP Catharanthus roseus
2.7.1.36 mevalonate 5-phosphate noncompetitive vs. ATP, mixed-type vs. mevalonate Catharanthus roseus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.36 0.076
-
mevalonate pH 7.5, 30°C Catharanthus roseus
2.7.1.36 0.13
-
ATP pH 7.5, 30°C Catharanthus roseus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.36 Co2+ approx. 18% of activity with Mg2+ or Mn2+ at 2 mM Catharanthus roseus
2.7.1.36 Fe2+ approx. 30% of activity with Mg2+ or Mn2+ at 2 mM Catharanthus roseus
2.7.1.36 Mn2+ divalent cation required for activity Catharanthus roseus
2.7.1.36 Mn2+ as effectiv as Mg2+ Catharanthus roseus
2.7.1.36 Zn2+ approx. 35% of activity with Mg2+ or Mn2+ at 2 mM Catharanthus roseus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.36 41500
-
2 * 41500, SDS-PAGE Catharanthus roseus
2.7.1.36 101900
-
additional bands at 19100, 23500, 45100, 73500 and 271200 Da, native PAGE Catharanthus roseus
2.7.1.36 104600
-
gel filtration Catharanthus roseus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.36 ATP + mevalonate Catharanthus roseus via mevalonate pathway involved in isoprenoid biosynthesis ADP + phosphomevalonate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.36 Catharanthus roseus
-
(L.) G. Don
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.36 Q-Sepharose, Phenyl-Sepharose, Mono Q, Shodex KW 803 Catharanthus roseus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.36 cell suspension culture
-
Catharanthus roseus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.36 10.6
-
-
Catharanthus roseus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.36 ATP + mevalonate
-
Catharanthus roseus ADP + phosphomevalonate
-
?
2.7.1.36 ATP + mevalonate via mevalonate pathway involved in isoprenoid biosynthesis Catharanthus roseus ADP + phosphomevalonate
-
?

Subunits

EC Number Subunits Comment Organism
2.7.1.36 dimer 2 * 41500, SDS-PAGE Catharanthus roseus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.36 8.9
-
broad optimum between pH 7.0 and pH 10.0 Catharanthus roseus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.1.36 5 10 approx. 10% of maximal activity at pH 5.0, approx. 90% of maximal activity at pH 10.0 Catharanthus roseus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.36 0.0001
-
farnesyl diphosphate pH 7.5, 30°C Catharanthus roseus