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Literature summary extracted from

  • Porter, J.W.
    Mevalonate kinase (1985), Methods Enzymol., 110, 71-78.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.36 farnesyl diphosphate
-
 Hevea brasiliensis
2.7.1.36 farnesyl diphosphate
-
 Phaseolus vulgaris
2.7.1.36 farnesyl diphosphate potent inhibitor Sus scrofa
2.7.1.36 geranyl diphosphate
-
 Hevea brasiliensis
2.7.1.36 geranyl diphosphate
-
 Phaseolus vulgaris
2.7.1.36 geranyl diphosphate potent inhibitor Sus scrofa
2.7.1.36 additional information
-
 Hevea brasiliensis
2.7.1.36 additional information not inhibited by isopentenyl and dimethyldiphosphate and phosphate Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.36 Mg2+ substrate MgATP Phaseolus vulgaris
2.7.1.36 Mg2+ substrate MgATP Staphylococcus aureus
2.7.1.36 Mg2+ substrate MgATP Rattus norvegicus
2.7.1.36 Mg2+ substrate MgATP Sus scrofa
2.7.1.36 Mg2+ substrate MgATP Saccharomyces cerevisiae
2.7.1.36 Mg2+ substrate MgATP Oryctolagus cuniculus
2.7.1.36 Mg2+ substrate MgATP Pinus radiata
2.7.1.36 Mg2+ substrate MgATP Citrus sp.
2.7.1.36 Mg2+ substrate MgATP Cucurbita pepo
2.7.1.36 Mg2+ substrate MgATP Hevea brasiliensis
2.7.1.36 Mg2+ substrate MgATP Cucumis melo
2.7.1.36 Mg2+ substrate MgATP Sarcophaga bullata
2.7.1.36 Mg2+ substrate MgATP Pinus pinaster
2.7.1.36 Mg2+ substrate MgATP Agave americana
2.7.1.36 Mg2+ substrate MgATP Kalanchoe crenata

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.36 98000
-
 gel filtration Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.36 Agave americana
-
-
-
2.7.1.36 Citrus sp.
-
 orange
-
2.7.1.36 Cucumis melo
-
-
-
2.7.1.36 Cucurbita pepo
-
 pumpkin
-
2.7.1.36 Hevea brasiliensis
-
 rubber tree
-
2.7.1.36 Kalanchoe crenata
-
-
-
2.7.1.36 Oryctolagus cuniculus
-
-
-
2.7.1.36 Phaseolus vulgaris
-
 french bean
-
2.7.1.36 Pinus pinaster
-
-
-
2.7.1.36 Pinus radiata
-
-
-
2.7.1.36 Rattus norvegicus
-
-
-
2.7.1.36 Saccharomyces cerevisiae
-
-
-
2.7.1.36 Sarcophaga bullata
-
 flesh fly
-
2.7.1.36 Staphylococcus aureus
-
-
-
2.7.1.36 Sus scrofa
-
 hog
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.36 ammonium sulfate, calcium phosphate gel, DEAE-cellulose, Sephadex G-200, DEAE-cellulose, Sephadex G-150 Sus scrofa

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.1.36 ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate sequential mechanism Sus scrofa
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.36 cotyledon
-
 Cucumis melo
-
2.7.1.36 cotyledon etiolated Phaseolus vulgaris
-
2.7.1.36 cotyledon etiolated Pinus pinaster
-
2.7.1.36 larva
-
 Sarcophaga bullata
-
2.7.1.36 latex
-
 Hevea brasiliensis
-
2.7.1.36 leaf
-
 Phaseolus vulgaris
-
2.7.1.36 leaf
-
 Pinus pinaster
-
2.7.1.36 leaf
-
 Agave americana
-
2.7.1.36 liver
-
 Rattus norvegicus
-
2.7.1.36 liver
-
 Sus scrofa
-
2.7.1.36 liver
-
 Oryctolagus cuniculus
-
2.7.1.36 ovary superovulated Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.36 17.5
-
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.36 ATP + (R)-mevalonate
-
 Sus scrofa ADP + (R)-5-phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Phaseolus vulgaris ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Staphylococcus aureus ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Rattus norvegicus ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Saccharomyces cerevisiae ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Oryctolagus cuniculus ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Pinus radiata ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Citrus sp. ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Cucurbita pepo ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Hevea brasiliensis ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Cucumis melo ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Sarcophaga bullata ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Pinus pinaster ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Agave americana ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate
-
 Kalanchoe crenata ADP + phosphomevalonate
-
 ?
2.7.1.36 ATP + mevalonate stereospecific reaction with R-mevalonate Sus scrofa ADP + phosphomevalonate
-
 ?

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.7.1.36 Sus scrofa isoelectric focusing 4.8 4.7