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Literature summary extracted from

  • McCormick, D.B.; Snell, E.E.
    Pyridoxal phosphokinase. II. Effects of inhibitors (1961), J. Biol. Chem., 236, 2085-2088.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.35 (2-Diethylaminoethyl)hydrazine 0.005 mM, 20% inhibition Bos taurus
2.7.1.35 1,1-Bis(2-diethylaminoethyl)hydrazine 0.005 mM, 51% inhibition Bos taurus
2.7.1.35 1,4-Diaminopiperazine 0.005 mM, 59% inhibition Bos taurus
2.7.1.35 1-(2-Hydrazinopropyl)piperidine 0.005 mM, 31% inhibition Bos taurus
2.7.1.35 1-(3-Dimethylamino-2-methylpropyl)hydrazine 0.005 mM, 39% inhibition Bos taurus
2.7.1.35 1-Aminopiperidine 0.005 mM, 58% inhibition Bos taurus
2.7.1.35 1-Cyclohexyl-1-methylhydrazine 0.005 mM, 29% inhibition Bos taurus
2.7.1.35 2,2'-hydrazinediethanol 0.005 mM, 47% inhibition Bos taurus
2.7.1.35 2,6-Dimethyl-3,4-bis(hydroxymethyl)pyridine
-
 Rattus norvegicus
2.7.1.35 2-Methyl-3-amino-4,5,6-tris(hydroxymethyl)pyridine
-
 Rattus norvegicus
2.7.1.35 2-Methyl-3-amino-4,5-bis(hydroxymethyl)pyridine
-
 Rattus norvegicus
2.7.1.35 2-Methyl-3-hydroxy-5,6-bis(hydroxymethyl)pyridine
-
 Rattus norvegicus
2.7.1.35 2-Methyl-4,5-bis(hydroxymethyl)pyridine
-
 Rattus norvegicus
2.7.1.35 2-[1-(2-Diethylaminoethyl)hydrazine]ethanol 0.005 mM, 44% inhibition Bos taurus
2.7.1.35 4-Aminomorpholine 0.005 mM, 52% inhibition Bos taurus
2.7.1.35 alpha-Methylphenethylhydrazine 0.001 mM, 50% inhibition Bos taurus
2.7.1.35 alpha-Methylphenethylhydrazine 0.015 mM, 50% inhibition Rattus norvegicus
2.7.1.35 alpha-Methylphenethylhydrazone 0.001 mM, 50% inhibition Bos taurus
2.7.1.35 alpha-Methylphenethylhydrazone 0.015 mM, 50% inhibition Rattus norvegicus
2.7.1.35 aminooxyacetic acid 0.002 mM, 50% inhibition Bos taurus
2.7.1.35 azine 0.000065 mM, 50% inhibition Bos taurus
2.7.1.35 azine 0.0004 mM, 50% inhibition Rattus norvegicus
2.7.1.35 hydrazine 0.00055 mM, 50% inhibition Bos taurus
2.7.1.35 hydrazine 0.05 mM, 50% inhibition Rattus norvegicus
2.7.1.35 hydroxylamine 0.0005 mM, 50% inhibition Bos taurus
2.7.1.35 hydroxylamine 0.01 mM, 50% inhibition Rattus norvegicus
2.7.1.35 L-canaline 0.01 mM, 50% inhibition Bos taurus
2.7.1.35 N,N'-Bis(pyridoxyl)hydrazine 0.0005 mM, 50% inhibition Bos taurus
2.7.1.35 Octylhydrazine 0.005 mM, 53% inhibition Bos taurus
2.7.1.35 Oxime 0.0025 mM, 50% inhibition Bos taurus
2.7.1.35 Oxime 0.008 mM, 50% inhibition Rattus norvegicus
2.7.1.35 pyridoxal semicarbazone 0.00005 mM, 50% inhibition Bos taurus
2.7.1.35 Semicarbazine 0.0005 mM, 50% inhibition Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.35 Bos taurus
-
-
-
2.7.1.35 Enterococcus faecalis
-
-
-
2.7.1.35 Lacticaseibacillus casei
-
-
-
2.7.1.35 Rattus norvegicus
-
-
-
2.7.1.35 Saccharomyces pastorianus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.35 brain
-
 Rattus norvegicus
-
2.7.1.35 brain
-
 Bos taurus
-
2.7.1.35 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.35 ATP + 4-deoxypyridoxine
-
 Saccharomyces pastorianus ADP + 4-deoxypyridoxine 5'-phosphate
-
 ?
2.7.1.35 ATP + 4-deoxypyridoxine
-
 Rattus norvegicus ADP + 4-deoxypyridoxine 5'-phosphate
-
 ?
2.7.1.35 ATP + 4-deoxypyridoxine
-
 Bos taurus ADP + 4-deoxypyridoxine 5'-phosphate
-
 ?
2.7.1.35 ATP + 4-deoxypyridoxine
-
 Enterococcus faecalis ADP + 4-deoxypyridoxine 5'-phosphate
-
 ?
2.7.1.35 ATP + 4-deoxypyridoxine
-
 Lacticaseibacillus casei ADP + 4-deoxypyridoxine 5'-phosphate
-
 ?
2.7.1.35 ATP + 5-deoxypyridoxal
-
 Saccharomyces pastorianus ADP + ?
-
 ?
2.7.1.35 ATP + 5-deoxypyridoxal
-
 Rattus norvegicus ADP + ?
-
 ?
2.7.1.35 ATP + 5-deoxypyridoxal
-
 Bos taurus ADP + ?
-
 ?
2.7.1.35 ATP + 5-deoxypyridoxal
-
 Enterococcus faecalis ADP + ?
-
 ?
2.7.1.35 ATP + 5-deoxypyridoxal
-
 Lacticaseibacillus casei ADP + ?
-
 ?
2.7.1.35 ATP + omega-methylpyridoxal
-
 Saccharomyces pastorianus ADP + omega-methylpyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + omega-methylpyridoxal
-
 Rattus norvegicus ADP + omega-methylpyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + omega-methylpyridoxal
-
 Bos taurus ADP + omega-methylpyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + omega-methylpyridoxal
-
 Enterococcus faecalis ADP + omega-methylpyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + omega-methylpyridoxal
-
 Lacticaseibacillus casei ADP + omega-methylpyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxal
-
 Saccharomyces pastorianus ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxal
-
 Rattus norvegicus ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxal
-
 Bos taurus ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxal
-
 Enterococcus faecalis ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxal
-
 Lacticaseibacillus casei ADP + pyridoxal 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxine
-
 Saccharomyces pastorianus ADP + pyridoxine 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxine
-
 Rattus norvegicus ADP + pyridoxine 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxine
-
 Bos taurus ADP + pyridoxine 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxine
-
 Enterococcus faecalis ADP + pyridoxine 5'-phosphate
-
 ?
2.7.1.35 ATP + pyridoxine
-
 Lacticaseibacillus casei ADP + pyridoxine 5'-phosphate
-
 ?