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Literature summary extracted from

  • Fuda, H.; Shimizu, C.; Lee, Y.C.; Akita, H.; Strott, C.A.
    Characterization and expression of human bifunctional 3'-phosphoadenosine 5'-phosphosulphate synthase isoforms (2002), Biochem. J., 365, 497-504.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.25 0.08
-
 ATP pH 8.0, 37°C, PAPSS 1 Homo sapiens
2.7.1.25 0.36
-
 ATP pH 8.0, 37°C, PAPSS 2b Homo sapiens
2.7.1.25 0.38
-
 ATP pH 8.0, 37°C, PAPSS 2a Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.25 Cavia porcellus O54820 guinea pig
-
2.7.1.25 Homo sapiens
-
 isoforms PAPSS 1, PAPSS 2a and 2b
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.25 adrenal gland PAPSS 1, 2a and 2b Homo sapiens
-
2.7.1.25 bone marrow PAPSS 1 Homo sapiens
-
2.7.1.25 brain PAPSS 1 Homo sapiens
-
2.7.1.25 cartilage PAPSS 1 is the predominant isoform in adults Homo sapiens
-
2.7.1.25 cartilage PAPSS 1 is the predominant isoform in adults Cavia porcellus
-
2.7.1.25 colon PAPSS 1, 2a and 2b Homo sapiens
-
2.7.1.25 kidney PAPSS 1, 2a and 2b Homo sapiens
-
2.7.1.25 liver PAPSS 1, 2a and 2b Homo sapiens
-
2.7.1.25 lung PAPSS 1, 2a and 2b Homo sapiens
-
2.7.1.25 ovary PAPSS 1, 2a and 2b Homo sapiens
-
2.7.1.25 placenta PAPSS 1, 2a and 2b Homo sapiens
-
2.7.1.25 prostate PAPSS 1 Homo sapiens
-
2.7.1.25 small intestine PAPSS 1, 2a and 2b Homo sapiens
-
2.7.1.25 spleen PAPSS 1, 2a and 2b Homo sapiens
-
2.7.1.25 stomach PAPSS 1 Homo sapiens
-
2.7.1.25 thymus PAPSS 1 Homo sapiens
-
2.7.1.25 thyroid gland PAPSS 1, 2a and 2b Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.25 ATP + adenosine 5-phosphosulfate i.e. adenylylsulfate or APS Homo sapiens ADP + 3'-phosphoadenosine 5'-phosphosulfate i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate ?
2.7.1.25 ATP + adenosine 5-phosphosulfate i.e. adenylylsulfate or APS Cavia porcellus ADP + 3'-phosphoadenosine 5'-phosphosulfate i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.1.25 1.7
-
 ATP pH 8.0, 37°C, PAPSS 1 Homo sapiens
2.7.1.25 2.3
-
 ATP pH 8.0, 37°C, PAPSS 2a Homo sapiens
2.7.1.25 4.4
-
 ATP pH 8.0, 37°C, PAPSS 2b Homo sapiens