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Literature summary extracted from

  • McGuiness, E.T.; Butler, J.R.
    NAD+ kinase-a review (1985), Int. J. Biochem., 17, 1-11.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.7.1.23 liver enzyme can be dialyzed at 4°C for at least 16 h with loss of activity and is also stable towards freezing and thawing Columba sp.
2.7.1.23 liver preparation is unstable to dialysis and repeated freezing and thawing Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.23 3-(bromoacetyl)pyridine
-
 Columba sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.23 cytoplasm
-
 Columba sp. 5737
-
2.7.1.23 cytoplasm the enzyme from skeletal muscle is susceptible to seasonal alterations: in autumn and winter, NADP+ synthesis proceeds maximally in the cytoplasm, in spring, higher activity is found in the mitochondrial fraction Oryctolagus cuniculus 5737
-
2.7.1.23 mitochondrion the enzyme from skeletal muscle is susceptible to seasonal alterations: in autumn and winter, NADP+ synthesis proceeds maximally in the cytoplasm, in spring, higher activity is found in the mitochondrial fraction Oryctolagus cuniculus 5739
-
2.7.1.23 soluble
-
 Oryctolagus cuniculus
-
-
2.7.1.23 soluble
-
 Spinacia oleracea
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.23 Achromobacter aceris
-
-
-
2.7.1.23 Azotobacter vinelandii
-
-
-
2.7.1.23 Bos taurus
-
-
-
2.7.1.23 Columba sp.
-
-
-
2.7.1.23 Corynebacterium ammoniagenes
-
-
-
2.7.1.23 Cyberlindnera jadinii
-
-
-
2.7.1.23 Gallus gallus
-
-
-
2.7.1.23 Homo sapiens O95544
-
-
2.7.1.23 Nicotiana tabacum
-
-
-
2.7.1.23 Oryctolagus cuniculus
-
-
-
2.7.1.23 Pisum sativum
-
-
-
2.7.1.23 Rattus norvegicus
-
-
-
2.7.1.23 Saccharomyces cerevisiae
-
-
-
2.7.1.23 Spinacia oleracea
-
-
-
2.7.1.23 Triatoma infestans
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.23 brain
-
 Rattus norvegicus
-
2.7.1.23 embryo fibroblast Columba sp.
-
2.7.1.23 erythrocyte
-
 Homo sapiens
-
2.7.1.23 fibroblast
-
 Homo sapiens
-
2.7.1.23 fibroblast from embryo Columba sp.
-
2.7.1.23 heart
-
 Columba sp.
-
2.7.1.23 kidney
-
 Oryctolagus cuniculus
-
2.7.1.23 leaf
-
 Spinacia oleracea
-
2.7.1.23 leaf
-
 Pisum sativum
-
2.7.1.23 leaf
-
 Nicotiana tabacum
-
2.7.1.23 liver
-
 Gallus gallus
-
2.7.1.23 liver
-
 Rattus norvegicus
-
2.7.1.23 liver
-
 Bos taurus
-
2.7.1.23 liver
-
 Oryctolagus cuniculus
-
2.7.1.23 liver
-
 Columba sp.
-
2.7.1.23 placenta
-
 Homo sapiens
-
2.7.1.23 polymorphonuclear leukocyte
-
 Homo sapiens
-
2.7.1.23 retina
-
 Rattus norvegicus
-
2.7.1.23 skeletal muscle
-
 Oryctolagus cuniculus
-
2.7.1.23 thyroid gland
-
 Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
2.7.1.23 4°C, 80% loss of activity after 7 days, no loss of activity after 5 days in presence of serum albumin Cyberlindnera jadinii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.23 ATP + 3-acetyl pyridineadenine dinucleotide
-
 Columba sp. ?
-
 ?
2.7.1.23 ATP + NAD+
-
 Gallus gallus ADP + NADP+
-
 ?
2.7.1.23 ATP + NAD+
-
 Cyberlindnera jadinii ADP + NADP+
-
 ?
2.7.1.23 ATP + NAD+
-
 Saccharomyces cerevisiae ADP + NADP+
-
 ?
2.7.1.23 ATP + NAD+
-
 Bos taurus ADP + NADP+
-
 ?
2.7.1.23 ATP + NAD+
-
 Pisum sativum ADP + NADP+
-
 ?
2.7.1.23 ATP + NAD+
-
 Azotobacter vinelandii ADP + NADP+
-
 ?
2.7.1.23 ATP + NAD+
-
 Columba sp. ADP + NADP+
-
 ?
2.7.1.23 ATP + NAD+
-
 Homo sapiens ADP + NADP+
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.7.1.23 60 68 stable for 5-30 min Columba sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.23 6.8 7
-
 Spinacia oleracea
2.7.1.23 6.8 7
-
 Nicotiana tabacum
2.7.1.23 7
-
-
 Gallus gallus
2.7.1.23 7
-
-
 Oryctolagus cuniculus
2.7.1.23 7 7.6 enzyme from liver Columba sp.
2.7.1.23 7.2 8
-
 Azotobacter vinelandii
2.7.1.23 7.2 8 enzyme from heart muscle Columba sp.
2.7.1.23 7.4 7.5
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.23 NAD+
-
 Gallus gallus
2.7.1.23 NAD+
-
 Cyberlindnera jadinii
2.7.1.23 NAD+
-
 Saccharomyces cerevisiae
2.7.1.23 NAD+
-
 Bos taurus
2.7.1.23 NAD+
-
 Pisum sativum
2.7.1.23 NAD+
-
 Azotobacter vinelandii
2.7.1.23 NAD+
-
 Columba sp.
2.7.1.23 NAD+
-
 Homo sapiens