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Literature summary extracted from

  • Wang, L.; Munch-Petersen, B.; Herrstrom Sjoberg, A.; Hellman, U.; Bergman, T.; Jornvall, H.; Eriksson, S.
    Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates (1999), FEBS Lett., 443, 170-174.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.21
-
Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.21 deoxcytidine poor inhibitor Homo sapiens
2.7.1.21 thymidine inhibition of deoxycytidine kinase activity Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.21 additional information
-
additional information
-
Homo sapiens
2.7.1.21 0.029
-
difluorodeoxyuridine
-
Homo sapiens
2.7.1.21 0.066
-
difluorodeoxycytidine
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.21 Homo sapiens O00142
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.21 rLyTK1Val-106 and rLyTK1Met-106 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.21 ATP + 2'-deoxycytidine
-
Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
?
2.7.1.21 ATP + arabinosyl cytosine
-
Homo sapiens ?
-
?
2.7.1.21 ATP + difluorodeoxycytidine
-
Homo sapiens ?
-
?
2.7.1.21 ATP + difluorodeoxyuridine
-
Homo sapiens ?
-
?
2.7.1.21 ATP + thymidine ATP can be substituted by CTP Homo sapiens ADP + dTMP
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.21 0.006
-
thymidine
-
Homo sapiens
2.7.1.21 0.63
-
deoxycytidine
-
Homo sapiens