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Literature summary extracted from

  • Swinton, D.C.; Chiang, K.S.
    Characterization of thymidine kinase and phosphorylation of deoxyribonucleosides in Chlamydomonas reinhardti (1979), Mol. Gen. Genet., 175, 399-409.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.21 5-bromodeoxyuridine
-
 Chlamydomonas reinhardtii
2.7.1.21 5-fluorodeoxyuridine
-
 Chlamydomonas reinhardtii
2.7.1.21 deoxyuridine
-
 Chlamydomonas reinhardtii
2.7.1.21 dTDP
-
 Chlamydomonas reinhardtii
2.7.1.21 dTTP
-
 Chlamydomonas reinhardtii
2.7.1.21 dUDP
-
 Chlamydomonas reinhardtii
2.7.1.21 dUTP
-
 Chlamydomonas reinhardtii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.21 0.00015
-
 thymidine pH 8.5, 30°C Chlamydomonas reinhardtii
2.7.1.21 0.015
-
 ATP pH 8.5, 30°C Chlamydomonas reinhardtii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.21 80000 85000 gel filtration Chlamydomonas reinhardtii

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.21 Chlamydomonas reinhardtii
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.1.21 ATP + thymidine = ADP + dTMP mechanism Chlamydomonas reinhardtii
a

Storage Stability

EC Number Storage Stability Organism
2.7.1.21 -20°C, 20 h Chlamydomonas reinhardtii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.21 ATP + thymidine ATP can be substituted by dCTP Chlamydomonas reinhardtii ADP + dTMP
-
 ?
2.7.1.21 ATP + thymidine ATP can be substituted by dATP Chlamydomonas reinhardtii ADP + dTMP
-
 ?
2.7.1.21 ATP + thymidine ATP can be substituted by CTP Chlamydomonas reinhardtii ADP + dTMP
-
 ?
2.7.1.21 additional information overview: phosphoryl donors Chlamydomonas reinhardtii ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.21 8.5
-
-
 Chlamydomonas reinhardtii

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.7.1.21 6.5
-
 best value for stability Chlamydomonas reinhardtii

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.21 0.00013
-
 5-bromodeoxyuridine pH 8.5, 30°C Chlamydomonas reinhardtii
2.7.1.21 0.00072
-
 5-fluorodeoxyuridine pH 8.5, 30°C Chlamydomonas reinhardtii
2.7.1.21 0.00146
-
 deoxyuridine pH 8.5, 30°C Chlamydomonas reinhardtii