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Literature summary extracted from

  • Yamada, Y.; Goto, H.; Ogasawara, N.
    Purine nucleoside kinases in human T- and B-lymphoblasts (1983), Biochim. Biophys. Acta, 761, 34-40.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.7.1.20 bovine serum albumin stabilizes Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.74 adenosine arabinoside weak, not with deoxyadenosine as substrate Homo sapiens
2.7.1.74 CTP strong, ATP as substrate Homo sapiens
2.7.1.74 cytidine weak Homo sapiens
2.7.1.74 cytosine arabinoside ATP as substrate; deoxycytidine as substrate; strong, deoxyadenosine as substrate Homo sapiens
2.7.1.74 dATP strong Homo sapiens
2.7.1.74 dCTP
-
 Homo sapiens
2.7.1.74 deoxyadenosine
-
 Homo sapiens
2.7.1.74 deoxycytidine deoxyadenosine as substrate Homo sapiens
2.7.1.74 deoxyguanosine deoxyguanosine as substrate, cytosolic isozyme I, weak Homo sapiens
2.7.1.74 dGTP ATP as substrate Homo sapiens
2.7.1.74 dTTP ATP as substrate; weak Homo sapiens
2.7.1.74 GTP not, deoxyadenosine as substrate; weak, ATP and deoxycytidine as substrate Homo sapiens
2.7.1.74 additional information little or no inhibition by AMP, dTMP, adenosine, guanosine Homo sapiens
2.7.1.74 Nucleosides overview, ATP and deoxyadenosine or deoxycytidine as substrate Homo sapiens
2.7.1.74 UTP ATP as substrate; not with deoxyadenosine as substrate Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.74 0.0033 0.0093 deoxycytidine
-
 Homo sapiens
2.7.1.74 0.15
-
 deoxyadenosine pH 8.0 Homo sapiens
2.7.1.74 0.33 0.43 deoxyguanosine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.20 cytosol
-
 Homo sapiens 5829
-
2.7.1.74 viral nucleocapsid Epstein-Barr-Virus Homo sapiens 19013
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.20 Homo sapiens
-
-
-
2.7.1.74 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.20 lymphoblast T-lymphoblast cell lines MILT 4F, CCRF CEM and RPMI 8402, B-lymphoblast cell lines BALL 1 and EBV (Epstein-Barr-virus)-transformed B-lymphoblast Homo sapiens
-
2.7.1.74 BALL-1 cell
-
 Homo sapiens
-
2.7.1.74 CCRF-CEM cell
-
 Homo sapiens
-
2.7.1.74 lymphoblast T-lymphoblasts, cell lines MOLT 4F, CCRF, CEM and RPMI 8402, B-lymphoblasts cell lines BALL 1 and EBV (Epstein-Barr-virus) transformed B-lymphoblasts Homo sapiens
-
2.7.1.74 MOLT-4F cell
-
 Homo sapiens
-
2.7.1.74 RPMI-8402 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.20 ATP + adenosine
-
 Homo sapiens ADP + AMP
-
 ?
2.7.1.74 ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 5'-dCMP
-
 ?
2.7.1.74 NTP + deoxyadenosine
-
 Homo sapiens NDP + dAMP
-
 ?
2.7.1.74 NTP + deoxycytidine
-
 Homo sapiens NDP + dCMP
-
 ?
2.7.1.74 NTP + deoxyguanosine
-
 Homo sapiens NDP + dGMP
-
 ?