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Literature summary extracted from

  • Doelle, H.W.
    Kinetic characteristics and regulatory mechanisms of glucokinase and fructokinase from Zymomonas mobilis (1982), Eur. J. Appl. Microbiol. Biotechnol., 14, 241-246.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.2 ADP
-
 Zymomonas mobilis
2.7.1.2 AMP
-
 Zymomonas mobilis
2.7.1.2 CTP above 1 mM, irrespective of glucose concentration Zymomonas mobilis
2.7.1.2 D-fructose 6-phosphate weak Zymomonas mobilis
2.7.1.2 D-glucose 6-phosphate
-
 Zymomonas mobilis
2.7.1.2 GTP above 1 mM, irrespective of glucose concentration Zymomonas mobilis
2.7.1.2 ITP above 1 mM, irrespective of glucose concentration Zymomonas mobilis
2.7.1.2 TTP above 1 mM, irrespective of glucose concentration Zymomonas mobilis
2.7.1.2 UTP above 1 mM, irrespective of glucose concentration Zymomonas mobilis
2.7.1.4 ADP
-
 Zymomonas mobilis
2.7.1.4 AMP inhibitory at low and stimulatory at high ATP concentration Zymomonas mobilis
2.7.1.4 ATP
-
 Zymomonas mobilis
2.7.1.4 D-fructose weak Zymomonas mobilis
2.7.1.4 D-glucose
-
 Zymomonas mobilis
2.7.1.4 D-glucose 6-phosphate
-
 Zymomonas mobilis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.2 0.11
-
 D-glucose + CTP, 30°C, pH 7 Zymomonas mobilis
2.7.1.2 0.12
-
 D-glucose + UTP, 30°C, pH 7 Zymomonas mobilis
2.7.1.2 0.2
-
 D-glucose + ITP, 30°C, pH 7 Zymomonas mobilis
2.7.1.2 0.22
-
 D-glucose cosubstrate GTP, 30°C, pH 7 Zymomonas mobilis
2.7.1.2 0.25
-
 GTP 30°C, pH 7 Zymomonas mobilis
2.7.1.2 0.36
-
 ITP 30°C, pH 7 Zymomonas mobilis
2.7.1.2 0.4
-
 ATP 30°C, pH 7 Zymomonas mobilis
2.7.1.2 0.5
-
 D-glucose + ATP, 30°C, pH 7 Zymomonas mobilis
2.7.1.2 0.56
-
 CTP 30°C, pH 7 Zymomonas mobilis
2.7.1.2 0.63
-
 UTP 30°C, pH 7 Zymomonas mobilis
2.7.1.2 0.8
-
 ATP 30°C, pH 7 Zymomonas mobilis
2.7.1.4 additional information
-
 additional information
-
 Zymomonas mobilis
2.7.1.4 0.07
-
 D-fructose with ATP as cosubstrate, pH 7.4, 30°C Zymomonas mobilis
2.7.1.4 0.16
-
 ATP
-
 Zymomonas mobilis
2.7.1.4 0.16
-
 ATP pH 7.4, 30°C Zymomonas mobilis
2.7.1.4 0.25
-
 ITP
-
 Zymomonas mobilis
2.7.1.4 0.25
-
 ITP pH 7.4, 30°C Zymomonas mobilis
2.7.1.4 0.26
-
 UTP
-
 Zymomonas mobilis
2.7.1.4 0.26
-
 UTP pH 7.4, 30°C Zymomonas mobilis
2.7.1.4 0.54
-
 D-fructose with UTP as cosubstrate, pH 7.4, 30°C Zymomonas mobilis
2.7.1.4 1.25
-
 D-fructose with ITP as cosubstrate, pH 7.4, 30°C Zymomonas mobilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.2 ATP + D-glucose Zymomonas mobilis
-
 ADP + D-glucose 6-phosphate
-
 ?
2.7.1.4 ATP + D-fructose Zymomonas mobilis
-
 ADP + D-fructose 6-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.2 Zymomonas mobilis
-
-
-
2.7.1.4 Zymomonas mobilis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.2 ATP + D-glucose
-
 Zymomonas mobilis ADP + D-glucose 6-phosphate
-
 ?
2.7.1.2 CTP + D-glucose
-
 Zymomonas mobilis CDP + D-glucose 6-phosphate
-
 ?
2.7.1.2 GTP + D-glucose
-
 Zymomonas mobilis GDP + D-glucose 6-phosphate
-
 ?
2.7.1.2 ITP + D-glucose
-
 Zymomonas mobilis IDP + D-glucose 6-phosphate
-
 ?
2.7.1.2 additional information enzyme reacts equally well with ATP, UTP, GTP, ITP and CTP Zymomonas mobilis ?
-
 ?
2.7.1.2 UTP + D-glucose
-
 Zymomonas mobilis UDP + D-glucose 6-phosphate
-
 ?
2.7.1.4 ATP + D-fructose
-
 Zymomonas mobilis ADP + D-fructose 6-phosphate
-
 ?
2.7.1.4 ATP + D-fructose specific for fructose Zymomonas mobilis ADP + D-fructose 6-phosphate
-
 ?
2.7.1.4 ATP + D-fructose specific for fructose and ATP Zymomonas mobilis ADP + D-fructose 6-phosphate
-
 ?
2.7.1.4 CTP + D-fructose no activity Zymomonas mobilis CDP + D-fructose 6-phosphate
-
 ?
2.7.1.4 ITP + D-fructose
-
 Zymomonas mobilis IDP + D-fructose 6-phosphate
-
 ?
2.7.1.4 additional information no activity with GTP Zymomonas mobilis ?
-
 ?
2.7.1.4 additional information no substrate: D-mannose Zymomonas mobilis ?
-
 ?
2.7.1.4 additional information no substrate: D-glucose Zymomonas mobilis ?
-
 ?
2.7.1.4 UTP + D-fructose
-
 Zymomonas mobilis UDP + D-fructose 6-phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.2 30
-
 assay at Zymomonas mobilis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.2 7
-
 2 optima: a major peak at pH 7.0 and a minor peak at pH 8.2 Zymomonas mobilis
2.7.1.2 8.2
-
 2 optima: a major peak at pH 7.0 and a minor peak at pH 8.2 Zymomonas mobilis
2.7.1.4 7.4
-
-
 Zymomonas mobilis

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.4 AMP inhibitory at low and stimulatory at high ATP concentration Zymomonas mobilis