EC Number | Application | Comment | Organism |
---|---|---|---|
2.7.11.14 | medicine | mutation in RK is associated with the Oguchi disease | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.11.14 | cloning of one GRK1 from cone-dominant retina | Gallus gallus |
2.7.11.14 | GRK1 and GRK1b are cloned from fovea, sequenced and expressed in Escherichia coli M15, GRK1b is a splice variant of GRK1 with low catalytic activity transcribed in photoreceptors, GRK1b is produced by retention of the last intron 6 and differs in its C-terminal region next to the catalytic domain | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.14 | Mg2+ | - |
Homo sapiens | |
2.7.11.14 | Mg2+ | - |
Gallus gallus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.14 | ATP + rhodopsin | Homo sapiens | important enzyme of phototransduction | ADP + phosphorhodopsin | - |
? | |
2.7.11.14 | ATP + rhodopsin | Gallus gallus | important enzyme of phototransduction | ADP + phosphorhodopsin | - |
? | |
2.7.11.14 | ATP + rhodopsin | Homo sapiens | light-dependent initiating of deactivation of rhodopsin | ADP + phosphorhodopsin | - |
? | |
2.7.11.14 | ATP + rhodopsin | Gallus gallus | light-dependent initiating of deactivation of rhodopsin | ADP + phosphorhodopsin | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.14 | Gallus gallus | O73685 | - |
- |
2.7.11.14 | Homo sapiens | - |
GRK1 and its splice variant GRK1b | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.11.14 | recombinant His-tagged GRK1 and GRK1b, expressed in Escherichia coli M15 | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.14 | eye | retina | Homo sapiens | - |
2.7.11.14 | eye | retina | Gallus gallus | - |
2.7.11.14 | pineal gland | expression of retinal GRK1 | Gallus gallus | - |
2.7.11.14 | retina | in rod and cone photoreceptors | Homo sapiens | - |
2.7.11.14 | retina | in rod and cone photoreceptors | Gallus gallus | - |
2.7.11.14 | retina | photoreceptors also transcribe the splice variant of GRK1 named GRK1b, which is not cone-specific | Homo sapiens | - |
2.7.11.14 | retina | rod-dominant retina, use of cone-enriched fovea, GRK1 occurs mainly in cone outer segments, to a lesser degree in rod outer segments, in all classes of cone cells | Homo sapiens | - |
2.7.11.14 | retina | cone-dominant retina | Gallus gallus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.14 | ATP + rhodopsin | highly specific for photobleached rhodopsin | Homo sapiens | ADP + phosphorhodopsin | - |
? | |
2.7.11.14 | ATP + rhodopsin | highly specific for photobleached rhodopsin | Gallus gallus | ADP + phosphorhodopsin | - |
? | |
2.7.11.14 | ATP + rhodopsin | important enzyme of phototransduction | Homo sapiens | ADP + phosphorhodopsin | - |
? | |
2.7.11.14 | ATP + rhodopsin | important enzyme of phototransduction | Gallus gallus | ADP + phosphorhodopsin | - |
? | |
2.7.11.14 | ATP + rhodopsin | light-dependent initiating of deactivation of rhodopsin | Homo sapiens | ADP + phosphorhodopsin | - |
? | |
2.7.11.14 | ATP + rhodopsin | light-dependent initiating of deactivation of rhodopsin | Gallus gallus | ADP + phosphorhodopsin | - |
? |