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Literature summary extracted from

  • Zhao, X.; Huang, J.; Khani, S.C.; Palczewski, K.
    Molecular forms of human rhodopsin kinase (GRK1) (1998), J. Biol. Chem., 273, 5124-5131.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.11.14 medicine mutation in RK is associated with the Oguchi disease Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.14 cloning of one GRK1 from cone-dominant retina Gallus gallus
2.7.11.14 GRK1 and GRK1b are cloned from fovea, sequenced and expressed in Escherichia coli M15, GRK1b is a splice variant of GRK1 with low catalytic activity transcribed in photoreceptors, GRK1b is produced by retention of the last intron 6 and differs in its C-terminal region next to the catalytic domain Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.14 Mg2+
-
Homo sapiens
2.7.11.14 Mg2+
-
Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.14 ATP + rhodopsin Homo sapiens important enzyme of phototransduction ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin Gallus gallus important enzyme of phototransduction ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin Homo sapiens light-dependent initiating of deactivation of rhodopsin ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin Gallus gallus light-dependent initiating of deactivation of rhodopsin ADP + phosphorhodopsin
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.14 Gallus gallus O73685
-
-
2.7.11.14 Homo sapiens
-
GRK1 and its splice variant GRK1b
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.14 recombinant His-tagged GRK1 and GRK1b, expressed in Escherichia coli M15 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.14 eye retina Homo sapiens
-
2.7.11.14 eye retina Gallus gallus
-
2.7.11.14 pineal gland expression of retinal GRK1 Gallus gallus
-
2.7.11.14 retina in rod and cone photoreceptors Homo sapiens
-
2.7.11.14 retina in rod and cone photoreceptors Gallus gallus
-
2.7.11.14 retina photoreceptors also transcribe the splice variant of GRK1 named GRK1b, which is not cone-specific Homo sapiens
-
2.7.11.14 retina rod-dominant retina, use of cone-enriched fovea, GRK1 occurs mainly in cone outer segments, to a lesser degree in rod outer segments, in all classes of cone cells Homo sapiens
-
2.7.11.14 retina cone-dominant retina Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.14 ATP + rhodopsin highly specific for photobleached rhodopsin Homo sapiens ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin highly specific for photobleached rhodopsin Gallus gallus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin important enzyme of phototransduction Homo sapiens ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin important enzyme of phototransduction Gallus gallus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin light-dependent initiating of deactivation of rhodopsin Homo sapiens ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin light-dependent initiating of deactivation of rhodopsin Gallus gallus ADP + phosphorhodopsin
-
?