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Literature summary extracted from

  • Rogers, J.C.; Williams, D.L.
    Kaempferol inhibits myosin light chain kinase (1989), Biochem. Biophys. Res. Commun., 164, 419-425.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 kaempferol i.e. 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-1-benzopyran-4-one, IC50: 0.00045 mM Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.11.18 0.005 0.0095 myosin light chain 30°C, pH 7.2 Bos taurus
2.7.11.18 0.075
-
 ATP
-
 Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Ca2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + myosin light chain Bos taurus obligatory step in development of active tension in smooth muscle ADP + myosin light chain phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 aorta thoracic Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin light chain
-
 Bos taurus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain obligatory step in development of active tension in smooth muscle Bos taurus ADP + myosin light chain phosphate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 Calmodulin requirement Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.18 0.00045
-
 i.e. 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-1-benzopyran-4-one, IC50: 0.00045 mM Bos taurus kaempferol