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Literature summary extracted from

  • Paxton, R.; Harris, R.A.
    Clofibric acid, phenylpyruvate, and dichloroacetate inhibition of branched-chain alpha-ketoacid dehydrogenase kinase in vitro and in perfused rat heart (1984), Arch. Biochem. Biophys., 231, 58-66.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.4 4-hydroxyphenylacetate
-
 Oryctolagus cuniculus
2.7.11.4 4-hydroxyphenyllactate weak Oryctolagus cuniculus
2.7.11.4 4-hydroxyphenylpyruvate very weak: 3-hydroxyphenylpyruvate Oryctolagus cuniculus
2.7.11.4 acetate weak, in vivo and in vitro Oryctolagus cuniculus
2.7.11.4 Clofibric acid in vivo and in vitro Oryctolagus cuniculus
2.7.11.4 Dichloroacetate
-
 Oryctolagus cuniculus
2.7.11.4 Dichloroacetate
-
 Rattus norvegicus
2.7.11.4 additional information no inhibition by lactate Oryctolagus cuniculus
2.7.11.4 additional information
-
 Rattus norvegicus
2.7.11.4 phenylacetate strong Oryctolagus cuniculus
2.7.11.4 Phenyllactate strong Oryctolagus cuniculus
2.7.11.4 phenylpyruvate in vivo and in vitro Oryctolagus cuniculus
2.7.11.4 pyruvate weak Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Rattus norvegicus phosphorylation inactivates EC 1.2.4.4 ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] Oryctolagus cuniculus phosphorylation inactivates EC 1.2.4.4 ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.4 Oryctolagus cuniculus
-
-
-
2.7.11.4 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.4
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.4 heart
-
 Rattus norvegicus
-
2.7.11.4 liver
-
 Rattus norvegicus
-
2.7.11.4 liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]
-
 Rattus norvegicus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]
-
 Oryctolagus cuniculus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphorylation inactivates EC 1.2.4.4 Rattus norvegicus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?
2.7.11.4 ATP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphorylation inactivates EC 1.2.4.4 Oryctolagus cuniculus ADP + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
-
 ?