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Literature summary extracted from

  • Barker, J.; Lewis, R.A.
    Deoxyguanosine kinase of neonatal mouse skin tissue (1981), Biochim. Biophys. Acta, 658, 111-123.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.7.1.113 ATP or MgATP2- stabilize, not Mg2+ alone Mus musculus
2.7.1.113 loss of activity in dilute solution Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.113 deoxyadenosine 0.07 mM, 9% inhibition Mus musculus
2.7.1.113 deoxyinosine 0.07 mM, 17% inhibition Mus musculus
2.7.1.113 dGDP 0.1 mM, 97% inhibition Mus musculus
2.7.1.113 dGMP
-
Mus musculus
2.7.1.113 dGTP 0.1 mM, 99% inhibition Mus musculus
2.7.1.113 dTDP
-
Mus musculus
2.7.1.113 additional information not inhibited by deoxyadenosine Mus musculus
2.7.1.113 UDP strong inhibition Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.113 0.007
-
deoxyguanosine pH 5.2, 37°C Mus musculus
2.7.1.113 0.023
-
ATP pH 5.2, 37°C, at concentrations below 0.5 mM Mus musculus
2.7.1.113 0.023
-
ATP ATP in form of MgATP2- Mus musculus
2.7.1.113 0.63
-
ATP pH 5.2, 37°C, at concentrations above 0.5 mM Mus musculus
2.7.1.113 0.63
-
ATP ATP in form of MgATP2- Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.113 soluble
-
Mus musculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.113 Ca2+ activation Mus musculus
2.7.1.113 Cd2+ slight activation Mus musculus
2.7.1.113 Mg2+ required for activity Mus musculus
2.7.1.113 Mn2+ can replace Mg2+ to some extent Mus musculus
2.7.1.113 Zn2+ activation, can replace Mg2+ to some extent Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.113 44000
-
glycerol density gradient centrifugation Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.113 ATP + deoxyguanosine Mus musculus first reaction in reutilization of deoxyguanosine for dGTP biosynthesis ADP + dGMP
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.113 Mus musculus
-
3 days old
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.113 pH 5.7, streptomycin sulfate, ammonium sulfate Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.113 skin neonatal skin tissue Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.113 0.0007
-
-
Mus musculus

Storage Stability

EC Number Storage Stability Organism
2.7.1.113 -20°C, ammonium sulfate precipitate in 100 mM M Tris-acetate buffer, pH 8, 0.025 M 2-mercaptoethanol, at least 4 months Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.113 ATP + deoxyguanosine no activity with deoxycytidine Mus musculus ADP + dGMP
-
?
2.7.1.113 ATP + deoxyguanosine no activity with dATP or GTP Mus musculus ADP + dGMP
-
?
2.7.1.113 ATP + deoxyguanosine no activity with deoxythymidine, uridine and cytosine Mus musculus ADP + dGMP
-
?
2.7.1.113 ATP + deoxyguanosine no activity with dGTP Mus musculus ADP + dGMP
-
?
2.7.1.113 ATP + deoxyguanosine no activity with adenosine Mus musculus ADP + dGMP
-
?
2.7.1.113 ATP + deoxyguanosine ATP can be replaced by dTTP, CTP, dCTP and UTP Mus musculus ADP + dGMP
-
?
2.7.1.113 ATP + deoxyguanosine 84%, 64%, 35% and 20% of activity with ATP with dTTP, CTP, dCTP and UTP, respectively Mus musculus ADP + dGMP
-
?
2.7.1.113 ATP + deoxyguanosine first reaction in reutilization of deoxyguanosine for dGTP biosynthesis Mus musculus ADP + dGMP
-
?
2.7.1.113 CTP + deoxyguanosine 64% of activity with ATP Mus musculus CDP + dGMP
-
?
2.7.1.113 dCTP + deoxyguanosine 35% of activity with ATP Mus musculus dCDP + dGMP
-
?
2.7.1.113 dTTP + deoxyguanosine 84% of activity with ATP Mus musculus dTDP + dGMP
-
?
2.7.1.113 UTP + deoxyguanosine 20% of activity with ATP Mus musculus UDP + dGMP
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.113 5.2
-
substrate deoxyguanosine Mus musculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.1.113 4.5 9 approx. 20% of maximal activity at pH 4.5 and pH 6.5 respectively, approx. 10% of maximal activity at pH 9.0 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.113 0.00007
-
dGTP pH 5.2, 37°C, competitive vs. MgATP2-, at MgATP2- concentrations above 0.5 mM Mus musculus
2.7.1.113 0.0007
-
dGDP pH 5.2, 37°C, competitive vs. MgATP2-, at MgATP2- concentrations above 0.5 mM Mus musculus
2.7.1.113 0.0019
-
dGTP pH 5.2, 37°C, competitive vs. deoxyguanosine Mus musculus
2.7.1.113 0.003
-
UDP pH 5.2, 37°C, competitive vs. MgATP2-, at MgATP2- concentrations above 0.5 mM Mus musculus
2.7.1.113 0.18
-
dGMP pH 5.2, 37°C, competitive vs. deoxyguanosine Mus musculus