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Literature summary extracted from

  • Itami, T.; Mueck, R.L.; Keenan, R.W.
    Dolichol kinase in rat sarcoplasmic reticulum membrane preparations (1988), Biochim. Biophys. Acta, 960, 374-381.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.108 Triton X-100
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.108 ATP
-
 Rattus norvegicus
2.7.1.108 GTP
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.108 0.023
-
 dolichol pH 7.4, 37°C Rattus norvegicus
2.7.1.108 1.5
-
 CTP pH 7.4, 37°C, skeletal muscle enzyme Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.108 membrane
-
 Rattus norvegicus 16020
-
2.7.1.108 microsome
-
 Rattus norvegicus
-
-
2.7.1.108 sarcoplasmic reticulum
-
 Rattus norvegicus 16529
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.108 Ca2+ activated almost equally well by Ca2+, Zn2+ or Mg2+ Rattus norvegicus
2.7.1.108 Mg2+ activated almost equally well by Ca2+, Zn2+ or Mg2+ Rattus norvegicus
2.7.1.108 additional information skeletal muscle kinase is not activated by Mn2+ Rattus norvegicus
2.7.1.108 Zn2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.108 CTP + dolichol Rattus norvegicus
-
 CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol Rattus norvegicus Sprague-Dawley
-
 CDP + dolichyl phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.108 Rattus norvegicus
-
 Sprague-Dawley
-
2.7.1.108 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.108 brain
-
 Rattus norvegicus
-
2.7.1.108 liver
-
 Rattus norvegicus
-
2.7.1.108 muscle leg muscle Rattus norvegicus
-
2.7.1.108 skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.108 CTP + dolichol
-
 Rattus norvegicus CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol
-
 Rattus norvegicus Sprague-Dawley CDP + dolichyl phosphate
-
 ?
2.7.1.108 additional information requires CTP as phosphoryl donor Rattus norvegicus ?
-
 ?
2.7.1.108 additional information requires CTP as phosphoryl donor Rattus norvegicus Sprague-Dawley ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.108 7.4 7.7
-
 Rattus norvegicus