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Literature summary extracted from

  • Sakakihara, Y.; Volpe, J.J.
    Zn2+, not Ca2+, is the most effective cation for activation of dolichol kinase of mammalian brain (1985), J. Biol. Chem., 260, 15413-15419.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.108 additional information
-
 Bos taurus
2.7.1.108 additional information trifluoperazine and chlorpromazine are no inhibitors Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.108 0.075
-
 dolichol pH 7.4, 37°C, brain enzyme Rattus norvegicus
2.7.1.108 1.62
-
 CTP pH 7.4, 37°C, brain enzyme Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.108 microsome
-
 Rattus norvegicus
-
-
2.7.1.108 microsome
-
 Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.108 Ca2+
-
 Rattus norvegicus
2.7.1.108 Ca2+
-
 Bos taurus
2.7.1.108 Cd2+ slight activation Rattus norvegicus
2.7.1.108 Co2+
-
 Rattus norvegicus
2.7.1.108 Co2+
-
 Bos taurus
2.7.1.108 Fe2+ slight activation Rattus norvegicus
2.7.1.108 Mg2+
-
 Rattus norvegicus
2.7.1.108 Mg2+
-
 Bos taurus
2.7.1.108 additional information
-
 Bos taurus
2.7.1.108 additional information not activated by Cu2+ Rattus norvegicus
2.7.1.108 Ni2+ slight activation Rattus norvegicus
2.7.1.108 Sr2+ slight activation Rattus norvegicus
2.7.1.108 Zn2+
-
 Bos taurus
2.7.1.108 Zn2+ most effective cation for activation of brain enzyme Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.108 CTP + dolichol Rattus norvegicus
-
 CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol Bos taurus
-
 CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol Rattus norvegicus Sprague-Dawley
-
 CDP + dolichyl phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.108 Bos taurus
-
 calf
-
2.7.1.108 Rattus norvegicus
-
 Sprague-Dawley
-
2.7.1.108 Rattus norvegicus
-
 cultured C-6 glial cells
-
2.7.1.108 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.108 brain
-
 Rattus norvegicus
-
2.7.1.108 brain
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.108 CTP + dolichol
-
 Rattus norvegicus CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol
-
 Bos taurus CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol
-
 Rattus norvegicus Sprague-Dawley CDP + dolichyl phosphate
-
 ?