Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Keller, R.K.; Rottler, G.D.; Cafmeyer, N.; Adair, W.L.
    Subcellular localization and substrate specificity of dolichol kinase from rat liver (1982), Biochim. Biophys. Acta, 719, 118-125.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.108 cytoplasm
-
 Rattus norvegicus 5737
-
2.7.1.108 endoplasmic reticulum
-
 Rattus norvegicus 5783
-
2.7.1.108 lysosome
-
 Rattus norvegicus 5764
-
2.7.1.108 membrane
-
 Rattus norvegicus 16020
-
2.7.1.108 microsome
-
 Rattus norvegicus
-
-
2.7.1.108 mitochondrion
-
 Rattus norvegicus 5739
-
2.7.1.108 nucleus
-
 Rattus norvegicus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.108 CTP + dolichol Rattus norvegicus enzyme can function in augmenting the steady-state levels of dolichyl phosphate by phosphorylating preexisting dolichol molecules CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol Rattus norvegicus Sprague-Dawley enzyme can function in augmenting the steady-state levels of dolichyl phosphate by phosphorylating preexisting dolichol molecules CDP + dolichyl phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.108 Rattus norvegicus
-
 rat
-
2.7.1.108 Rattus norvegicus
-
 Sprague-Dawley
-
2.7.1.108 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.108
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.108 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.108 0.15
-
 relative specific activity in the soluble fraction Rattus norvegicus
2.7.1.108 0.21
-
 relative specific activity in the mitochondrial lysosomal fraction Rattus norvegicus
2.7.1.108 0.52
-
 relative specific activity in the nuclear fraction Rattus norvegicus
2.7.1.108 3.8
-
 relative specific activity in the microsomal fraction, rough and smooth endoplasmic reticulum are found to have higher specific activities than the Golgi fraction Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.108 CTP + dolichol pig liver dolichol as substrate, R,S-dolichol-11, dolichol-16, dolichol-19 Rattus norvegicus CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol enzyme can function in augmenting the steady-state levels of dolichyl phosphate by phosphorylating preexisting dolichol molecules Rattus norvegicus CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol pig liver dolichol as substrate, R,S-dolichol-11, dolichol-16, dolichol-19 Rattus norvegicus Sprague-Dawley CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + dolichol enzyme can function in augmenting the steady-state levels of dolichyl phosphate by phosphorylating preexisting dolichol molecules Rattus norvegicus Sprague-Dawley CDP + dolichyl phosphate
-
 ?
2.7.1.108 CTP + ficaprenol
-
 Rattus norvegicus CDP + ficaprenyl phosphate
-
 ?
2.7.1.108 CTP + ficaprenol
-
 Rattus norvegicus Sprague-Dawley CDP + ficaprenyl phosphate
-
 ?
2.7.1.108 CTP + polyprenol polyprenol-16, alpha-trans-polyprenol-16, polyprenol-19 Rattus norvegicus CDP + polyprenyl phosphate
-
 ?
2.7.1.108 CTP + polyprenol polyprenol-16, alpha-trans-polyprenol-16, polyprenol-19 Rattus norvegicus Sprague-Dawley CDP + polyprenyl phosphate
-
 ?
2.7.1.108 additional information microsomal enzyme shows a marked preference for saturation of the alpha-isoprene, dolichol-16 and dolichol-19 are 2.5fold more active than the corresponding polyprenols, the enzyme is twice as active against naturally occurring polyprenol-16 (alpha-cis-isoprene) compared to synthetic alpha-trans-polyprenol-16, all-trans-2,3-dihydrosolanesol and solanesol are not substrates Rattus norvegicus ?
-
 ?
2.7.1.108 additional information microsomal enzyme shows a marked preference for saturation of the alpha-isoprene, dolichol-16 and dolichol-19 are 2.5fold more active than the corresponding polyprenols, the enzyme is twice as active against naturally occurring polyprenol-16 (alpha-cis-isoprene) compared to synthetic alpha-trans-polyprenol-16, all-trans-2,3-dihydrosolanesol and solanesol are not substrates Rattus norvegicus Sprague-Dawley ?
-
 ?