EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.1 | acetate | noncompetitive to glucose | Rattus norvegicus | |
2.7.1.1 | Br- | noncompetitive to glucose | Rattus norvegicus | |
2.7.1.1 | Cl- | noncompetitive to glucose | Rattus norvegicus | |
2.7.1.1 | F- | noncompetitive to glucose | Rattus norvegicus | |
2.7.1.1 | I- | noncompetitive to glucose | Rattus norvegicus | |
2.7.1.1 | additional information | enzymes from rat brain and bovine heart are not inhibited by palmitoyl-CoA or regulatory protein | Bos taurus | |
2.7.1.1 | additional information | enzymes from rat brain and bovine heart are not inhibited by palmitoyl-CoA or regulatory protein | Rattus norvegicus | |
2.7.1.1 | additional information | - |
Sus scrofa | |
2.7.1.1 | N-acetyl-D-glucosamine | - |
Rattus norvegicus | |
2.7.1.1 | NO3- | noncompetitive to glucose | Rattus norvegicus | |
2.7.1.1 | palmitoyl-CoA | inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast; inhibitor binds to a site distinct from the catalytic site, noncompetitive to MgATP2-, competitive to glucose, synergistic with N-acetylglucosamine | Rattus norvegicus | |
2.7.1.1 | palmitoyl-CoA | inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast | Rhinella marina | |
2.7.1.1 | palmitoyl-CoA | inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast | Sus scrofa | |
2.7.1.1 | phosphate | noncompetitive to glucose | Rattus norvegicus | |
2.7.1.1 | phosphate | - |
Sus scrofa | |
2.7.1.1 | Regulatory protein | inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast; inhibitor binds to a site distinct from the catalytic site, noncompetitive to MgATP2-, competitive to glucose, synergistic with N-acetylglucosamine, phosphate and sulfate decrease inhibition, monovalent anions antagonize inhibition with the following decreasing order of potency: I-, Br-, NO3-, Cl-, F-, acetate | Rattus norvegicus | |
2.7.1.1 | Regulatory protein | inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast | Rhinella marina | |
2.7.1.1 | Regulatory protein | inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast | Sus scrofa | |
2.7.1.1 | SO42- | noncompetitive to glucose | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.1 | 0.1 | - |
2-deoxy-D-glucose | rat brain enzyme, hexokinase I | Rattus norvegicus | |
2.7.1.1 | 0.125 | - |
2-deoxy-D-glucose | - |
Bos taurus | |
2.7.1.1 | 0.125 | - |
2-deoxy-D-glucose | bovine heart enzyme, hexokinase II | Rattus norvegicus | |
2.7.1.1 | 5.5 | - |
D-glucose | hexokinase IV | Sus scrofa | |
2.7.1.1 | 9 | - |
2-deoxy-D-glucose | rat liver enzyme, hexokinase IV | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.1 | Bos taurus | - |
hexokinase II | - |
2.7.1.1 | Rattus norvegicus | - |
hexokinase IV or D | - |
2.7.1.1 | Rhinella marina | - |
- |
- |
2.7.1.1 | Sus scrofa | - |
hexokinase IV | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.1 | - |
Rattus norvegicus |
2.7.1.1 | - |
Sus scrofa |
2.7.1.1 | - |
Rhinella marina |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.1 | heart | - |
Bos taurus | - |
2.7.1.1 | liver | - |
Sus scrofa | - |
2.7.1.1 | liver | hexokinase IV or D | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.1 | ATP + 2-deoxy-D-glucose | - |
Rattus norvegicus | ADP + 2-deoxy-D-glucose 6-phosphate | - |
? | |
2.7.1.1 | ATP + 2-deoxy-D-glucose | - |
Sus scrofa | ADP + 2-deoxy-D-glucose 6-phosphate | - |
? | |
2.7.1.1 | ATP + 2-deoxy-D-glucose | - |
Bos taurus | ADP + 2-deoxy-D-glucose 6-phosphate | - |
? | |
2.7.1.1 | D-glucose + ATP | - |
Rattus norvegicus | ADP + D-glucose 6-phosphate | - |
? | |
2.7.1.1 | D-glucose + ATP | - |
Sus scrofa | ADP + D-glucose 6-phosphate | - |
? | |
2.7.1.1 | D-glucose + ATP | - |
Bos taurus | ADP + D-glucose 6-phosphate | - |
? | |
2.7.1.1 | D-glucose + ATP | - |
Rhinella marina | ADP + D-glucose 6-phosphate | - |
? | |
2.7.1.1 | D-mannose + ATP | - |
Rattus norvegicus | ADP + D-mannose 6-phosphate | - |
? | |
2.7.1.1 | D-mannose + ATP | - |
Sus scrofa | ADP + D-mannose 6-phosphate | - |
? | |
2.7.1.1 | additional information | - |
Sus scrofa | ? | - |
? | |
2.7.1.1 | additional information | not: D-galactose | Rattus norvegicus | ? | - |
? | |
2.7.1.1 | additional information | not: trehalose | Rattus norvegicus | ? | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.1 | ATP | - |
Rattus norvegicus | |
2.7.1.1 | ATP | - |
Sus scrofa | |
2.7.1.1 | ATP | - |
Bos taurus | |
2.7.1.1 | ATP | - |
Rhinella marina |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.1 | 0.0035 | - |
palmitoyl-CoA | - |
Rattus norvegicus | |
2.7.1.1 | 1.6 | - |
palmitoyl-CoA | - |
Sus scrofa |