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Literature summary extracted from

  • Walker, J.B.
    Enzymic synthesis of aminocyclitol moieties of aminoglycoside antibiotics from inositol by Streptomyces sp.: detection of glutamine-aminocyclitol aminotransferase and diaminocyclitol aminotransferase activities in a spectinomycin producer (1995), J. Bacteriol., 177, 818-822.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.6.1.50 pharmacology 5'-hydroxystreptomycin production Streptomyces griseocarneus
2.6.1.50 pharmacology spectinomycin production Streptomyces netropsis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.50 L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone Streptomyces netropsis
-
 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol
-
 r
2.6.1.50 L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone Streptomyces hygroscopicus
-
 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol
-
 r
2.6.1.50 L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone Streptomyces griseocarneus
-
 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.50 Streptomyces griseocarneus
-
 ATCC 12628
-
2.6.1.50 Streptomyces hygroscopicus
-
 subsp. glebosus ATCC 14607
-
2.6.1.50 Streptomyces netropsis
-
 ATCC 19756
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.50 mycelium
-
 Streptomyces netropsis
-
2.6.1.50 mycelium
-
 Streptomyces hygroscopicus
-
2.6.1.50 mycelium
-
 Streptomyces griseocarneus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.50 L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone
-
 Streptomyces netropsis 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol
-
 r
2.6.1.50 L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone
-
 Streptomyces hygroscopicus 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol
-
 r
2.6.1.50 L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone
-
 Streptomyces griseocarneus 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol
-
 r
2.6.1.50 myo-inositol + diaminocyclitol + oxaloacetate
-
 Streptomyces netropsis amino-deoxyinositol + ketoaminocyclitol + malate
-
 r
2.6.1.50 myo-inositol + diaminocyclitol + oxaloacetate
-
 Streptomyces hygroscopicus amino-deoxyinositol + ketoaminocyclitol + malate
-
 r
2.6.1.50 myo-inositol + glutamine + oxalacetate
-
 Streptomyces netropsis amino-deoxyinositol + 2-oxoglutarate + malate + NH4+
-
 r
2.6.1.50 myo-inositol + glutamine + oxalacetate
-
 Streptomyces hygroscopicus amino-deoxyinositol + 2-oxoglutarate + malate + NH4+
-
 r
2.6.1.50 N3-methyl-2-deoxy-streptamine + inosose
-
 Streptomyces netropsis aminodeoxyinositol + 1-keto-2-deoxy-3-methylaminodeoxy-scyllo-inositol
-
 r
2.6.1.50 N3-methyl-2-deoxy-streptamine + inosose
-
 Streptomyces hygroscopicus aminodeoxyinositol + 1-keto-2-deoxy-3-methylaminodeoxy-scyllo-inositol
-
 r
2.6.1.50 N3-methyl-2-deoxy-streptamine + inosose
-
 Streptomyces griseocarneus aminodeoxyinositol + 1-keto-2-deoxy-3-methylaminodeoxy-scyllo-inositol
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.6.1.50 L-glutamine:inosose aminotransferase
-
 Streptomyces netropsis