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Literature summary extracted from

  • Hu, Ch.Y.; Sprinson, D.B.
    Properties of tyrosine-inhibitable 3-deoxy-D-arabinoheptulosonic acid-7-phosphate synthase from Salmonella (1977), J. Bacteriol., 129, 177-183.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.54 (1R,2S)-1,2-epoxypropylphosphonic acid
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.5.1.54 (Z)-Phosphoenol 3-fluoropyruvate
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.5.1.54 Phosphoenol 2-oxobutanoate
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.5.1.54 Tyr noncompetitive with respect to D-erythrose 4-phosphate, competitive with respect to phosphoenolpyruvate; Tyr-sensitive isozyme Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.54 40000
-
 2 * 40000, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
2.5.1.54 76000
-
 gel filtration Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.54 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
2.5.1.54 Salmonella enterica subsp. enterica serovar Typhimurium
-
 tyrosine-sensitive isozyme
-
2.5.1.54 Salmonella enterica subsp. enterica serovar Typhimurium
-
 operator-constitutive strain tyrO
-
2.5.1.54 Salmonella enterica subsp. enterica serovar Typhimurium SG12
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.54 173fold Salmonella enterica subsp. enterica serovar Typhimurium

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.54 37.5
-
 purified enzyme Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.54 phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
 ?
2.5.1.54 phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium SG12 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.54 dimer 2 * 40000, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium