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Literature summary extracted from

  • Bitonti, A.J.; Kelly, S.E.; McCann, P.P.
    Characterization of spermidine synthase from Trypanosoma brucei brucei (1984), Mol. Biochem. Parasitol., 13, 21-28.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.16 Cyclohexylamine in vitro, 50% inhibition at 0.015 mM, competitive with 1,4-diaminobutane Trypanosoma brucei brucei
2.5.1.16 S-Adenosyl-1,8-diamino-3-thiooctane potent, 50% inhibition at 0.025 mM Trypanosoma brucei brucei

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.16 74000
-
 gel filtration and sucrose density gradient centrifugation Trypanosoma brucei brucei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane Trypanosoma brucei brucei
-
 5'-methylthioadenosine + spermidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.16 Trypanosoma brucei brucei
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.16 S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Trypanosoma brucei brucei 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Trypanosoma brucei brucei 5'-methylthioadenosine + spermidine
-
 ?