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Literature summary extracted from

  • Nopponpunth, V.; Sirawaraporn, W.; Greene, P.J.; Santi, D.V.
    Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coli (1999), J. Bacteriol., 181, 6814-6821.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.15 expression in dihydroxypteroate synthase deficient strain of Escherichia coli Mycobacterium tuberculosis
2.5.1.15 expression in dihydroxypteroate synthase deficient strain of Escherichia coli Mycobacterium leprae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.15 dapsone
-
Mycobacterium leprae
2.5.1.15 dapsone
-
Mycobacterium tuberculosis
2.5.1.15 p-Aminosalicylate
-
Mycobacterium leprae
2.5.1.15 p-Aminosalicylate
-
Mycobacterium tuberculosis
2.5.1.15 sulfamethoxazole
-
Mycobacterium leprae
2.5.1.15 sulfamethoxazole
-
Mycobacterium tuberculosis
2.5.1.15 sulfamethoxypyridazine
-
Mycobacterium leprae
2.5.1.15 sulfamethoxypyridazine
-
Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.15 0.00037
-
p-Aminobenzoic acid
-
Mycobacterium tuberculosis
2.5.1.15 0.0006
-
p-Aminobenzoic acid
-
Mycobacterium leprae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.15 60000
-
gel filtration of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase Mycobacterium tuberculosis
2.5.1.15 60000
-
gel filtration of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase Mycobacterium leprae

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.15 Mycobacterium leprae P0C0X1
-
-
2.5.1.15 Mycobacterium tuberculosis P9WND1
-
-
2.5.1.15 Mycobacterium tuberculosis H37Rv P9WND1
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.15 mycobacterial enzymes, from DEAE-Sepharose and other chromatography steps Mycobacterium tuberculosis
2.5.1.15 mycobacterial enzymes, from DEAE-Sepharose and other chromatography steps Mycobacterium leprae

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.15 0.174
-
recombinant enzyme Mycobacterium leprae
2.5.1.15 0.596
-
recombinant enzyme Mycobacterium tuberculosis

Storage Stability

EC Number Storage Stability Organism
2.5.1.15 -80ºC, pH 7.0, 20% glycerol, 10-30% loss of activity in 1 month Mycobacterium tuberculosis
2.5.1.15 -80ºC, pH 7.0, 20% glycerol, 10-30% loss of activity in 1 month Mycobacterium leprae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
Mycobacterium tuberculosis diphosphate + 7,8-dihydropteroate
-
?
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
Mycobacterium leprae diphosphate + 7,8-dihydropteroate
-
?
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
Mycobacterium tuberculosis H37Rv diphosphate + 7,8-dihydropteroate
-
?

Subunits

EC Number Subunits Comment Organism
2.5.1.15 dimer
-
Mycobacterium tuberculosis
2.5.1.15 dimer
-
Mycobacterium leprae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.15 8
-
-
Mycobacterium leprae
2.5.1.15 9
-
-
Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.15 0.000011
-
dapsone
-
Mycobacterium leprae
2.5.1.15 0.000013
-
dapsone
-
Mycobacterium tuberculosis
2.5.1.15 0.000025
-
sulfamethoxypyridazine
-
Mycobacterium leprae
2.5.1.15 0.000028
-
sulfamethoxazole
-
Mycobacterium tuberculosis
2.5.1.15 0.00003
-
sulfamethoxazole
-
Mycobacterium leprae
2.5.1.15 0.000031
-
sulfamethoxypyridazine
-
Mycobacterium tuberculosis