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Literature summary extracted from

  • Vedantam, G.; Nichols, B.P.
    Characterization of a mutationally altered dihydropteroate synthase contributing to sulfathiazole resistance in Escherichia coli (1998), Microb. Drug Resist., 4, 91-97.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.15 sulfathiazole competitive to 4-aminobenzoate Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.15 additional information
-
 additional information values for recombinant enzymes Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.15 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.15 Q-Sepharose column Escherichia coli

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.15 additional information
-
 specific activity in different strains Escherichia coli
2.5.1.15 0.0000483
-
 crude extract of Escherichia coli MG1655 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
 Escherichia coli diphosphate + 7,8-dihydropteroate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.15 additional information
-
 additional information KI values of sulfathiazole for wild-type and mutant enzyme Escherichia coli