Literature summary extracted from

McCullough, J.L.; Maren, T.H.
Dihydropteroate synthetase from Plasmodium berghei: isolation, properties, and inhibition by dapsone and sulfadiazine (1974), Mol. Pharmacol., 10, 140-145.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.5.1.15	4,4-Diaminodiphenyl sulfone	-	Plasmodium berghei
2.5.1.15	Sulfadiazine	-	Plasmodium berghei

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.5.1.15	0.0014	-	2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate	-	Plasmodium berghei
2.5.1.15	0.0028	-	4-Aminobenzoic acid	-	Plasmodium berghei

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.15	Plasmodium berghei	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.15	2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate	-	Plasmodium berghei	diphosphate + 7,8-dihydropteroate	-	?

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
2.5.1.15	8.5	-	-	Plasmodium berghei

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Release 2023.1 (January 2023)