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Literature summary extracted from

  • Orozco, A.; Silva, J.E.; Valverde-R, C.
    Rainbow trout liver expresses two iodothyronine phenolic ring deiodinase pathways with the characteristics of mammalian types I and II 5'-deiodinases (1997), Endocrinology, 138, 254-258.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.21.99.4 reduced thiols
-
 Rattus sp.
1.21.99.4 reduced thiols e.g. dithiothreitol Oncorhynchus mykiss

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.4 6-Propyl-2-thiouracil only type II sensitive to inhibition Oncorhynchus mykiss
1.21.99.4 6-Propyl-2-thiouracil
-
 Rattus sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.99.4 0.18
-
 3,3',5'-triiodothyronine type I, liver Oncorhynchus mykiss

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2 Gallus gallus
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 Oncorhynchus mykiss isoenzyme type I 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 Rattus sp. isoenzyme type I 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2 Oncorhynchus mykiss thyronine 5'-deiodinase type II 3,3',5-triiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2 Rattus sp. thyronine 5'-deiodinase type II 3,3',5-triiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2 Oncorhynchus mykiss idothyronine 5'-deiodinase type I 3,3',5'-triiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2 Rattus sp. idothyronine 5'-deiodinase type I 3,3',5'-triiodothyronine + iodide + A + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.4 Gallus gallus
-
-
-
1.21.99.4 Lithobates catesbeianus
-
-
-
1.21.99.4 Oncorhynchus mykiss
-
-
-
1.21.99.4 Rattus sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.4 liver type I and II Gallus gallus
-
1.21.99.4 liver type II and III Lithobates catesbeianus
-
1.21.99.4 liver thyronine 5'-deiodinase type I Oncorhynchus mykiss
-
1.21.99.4 liver thyronine 5'-deiodinase type I Rattus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2
-
 Gallus gallus 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 isoenzyme type I Oncorhynchus mykiss 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 isoenzyme type I Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2 thyronine 5'-deiodinase type II Oncorhynchus mykiss 3,3',5-triiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2 thyronine 5'-deiodinase type II Rattus sp. 3,3',5-triiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2 idothyronine 5'-deiodinase type I Oncorhynchus mykiss 3,3',5'-triiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 L-thyroxine + AH2 idothyronine 5'-deiodinase type I Rattus sp. 3,3',5'-triiodothyronine + iodide + A + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.99.4 iodothyronine 5'-deiodinase
-
 Oncorhynchus mykiss
1.21.99.4 iodothyronine 5'-deiodinase
-
 Rattus sp.
1.21.99.4 iodothyronine inner ring monodeiodinase
-
 Rattus sp.
1.21.99.4 iodothyronine inner ring monodeiodinase isoenzyme type III Lithobates catesbeianus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.21.99.4 23 25
-
 Oncorhynchus mykiss

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.21.99.4 7
-
-
 Oncorhynchus mykiss
1.21.99.4 7
-
-
 Rattus sp.