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Literature summary extracted from

  • Shaw, L.; Schneckenburger, P.; Carlsen, J.; Christiansen, K.; Schauer, R.
    Mouse liver cytidine-5-monophosphate-N-acetylneuraminic acid hydroxylase. Catalytic function and regulation (1992), Eur. J. Biochem., 206, 269-277.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.18.2 decyl glucoside activation Mus musculus
1.14.18.2 additional information highest activity in 50 mM Hepes buffer, significant inhibition at increasing concentrations Mus musculus
1.14.18.2 Nonidet P-40 effective inhibitor Mus musculus
1.14.18.2 octanoic acid 1 mM, modest activation Mus musculus
1.14.18.2 octyl glucoside effective inhibitor Mus musculus
1.14.18.2 SDS 1 mM, modest activation Mus musculus
1.14.18.2 Triton X-100 effective inhibitor Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.2 1,10-phenanthroline 5 mM, complete inhibition Mus musculus
1.14.18.2 anti-(rat cytochrome b5) antiserum
-
Mus musculus
1.14.18.2 cardiolipin 3 mM, 15% inhibition Mus musculus
1.14.18.2 CMP-N-glycoloylneuraminate
-
Mus musculus
1.14.18.2 ferrozine 0.7 mM, 82% inhibition Mus musculus
1.14.18.2 KCN 5 mM, 49% inhibition Mus musculus
1.14.18.2 Na2HPO4 2 mM, 86% inhibition Mus musculus
1.14.18.2 Na4P2O7 2 mM, 54% loss of activity Mus musculus
1.14.18.2 phosphatidic acid 3 mM, 20% inhibition Mus musculus
1.14.18.2 phosphatidylinositol 3 mM, 68% inhibition Mus musculus
1.14.18.2 Tiron 5 mM, 82% inhibition Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.18.2 17000
-
gel filtration Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.2 liver
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + ferrocytochrome b5 + O2 the electron carrier cytochrome b5 is essential for activity Mus musculus CMP-N-glycoloylneuraminate + ferricytrochrome b5 + H2O
-
?
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2
-
Mus musculus CMP-N-glycoloylneuraminate + NAD+ + H2O
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.18.2 6.8 7.4
-
Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.18.2 ferrocytochrome b5 the electron carrier cytochrome b5 is essential for activity Mus musculus
1.14.18.2 NADH
-
Mus musculus