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Literature summary extracted from

  • Townsend, C.A.
    New reactions in clavulanic acid biosynthesis (2002), Curr. Opin. Chem. Biol., 6, 583-589.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.21 Fe2+ required Streptomyces clavuligerus
1.14.11.21 Fe2+ conformation during catalytic reaction Streptomyces clavuligerus
1.14.11.21 Fe2+ isozyme CS2, five and six-coordinate ferrous species in the enzyme-substrate complexes, structural model of conversion for the different reactions Streptomyces clavuligerus
1.14.11.21 Fe2+ no ligand switching among the histidine residues of the protein Streptomyces clavuligerus
1.14.11.21 Fe2+ isozyme CS2, a single ferrous active site Streptomyces clavuligerus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.3.4 54500
-
x * 54500, deduced from gene sequence Streptomyces clavuligerus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.21 deoxyguanidinoproclavaminate + 2-oxoglutarate + O2 Streptomyces clavuligerus
-
guanidinoproclavaminate + succinate + CO2 + H2O
-
?
1.14.11.21 dihydroclavaminate + 2-oxoglutarate + O2 Streptomyces clavuligerus
-
clavaminate + succinate + CO2 + H2O
-
?
1.14.11.21 additional information Streptomyces clavuligerus biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor ?
-
?
1.14.11.21 proclavaminate + 2-oxoglutarate + O2 Streptomyces clavuligerus
-
dihydroclavaminate + succinate + CO2 + H2O
-
?
6.3.3.4 N2-(carboxyethyl)-L-arginine + ATP Streptomyces clavuligerus overview on biological role AMP + diphosphate + deoxyamidinoproclavaminate
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.21 Streptomyces clavuligerus
-
2 isozymes CS1 and CS2
-
1.14.11.21 Streptomyces clavuligerus
-
isozyme CS2 is encoded on orf5
-
6.3.3.4 Streptomyces clavuligerus P0DJQ7
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.11.21 deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 this reaction is due to a proclavaminate amidinohydrolase PAH, gene cla Streptomyces clavuligerus
6.3.3.4 ATP + L-N2-(2-carboxyethyl)arginine = AMP + diphosphate + deoxyamidinoproclavaminate overview Streptomyces clavuligerus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.21 deoxyamidinoproclavaminate + 2-oxoglutarate + O2 this reaction is due to a proclavaminate amidinohydrolase, i.e. cla Streptomyces clavuligerus amidinoproclavaminate + succinate + CO2 + H2O
-
?
1.14.11.21 deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
-
Streptomyces clavuligerus guanidinoproclavaminate + succinate + CO2 + H2O
-
?
1.14.11.21 deoxyguanidinoproclavaminate + 2-oxoglutarate + O2 hydroxylation Streptomyces clavuligerus guanidinoproclavaminate + succinate + CO2 + H2O
-
?
1.14.11.21 dihydroclavaminate + 2-oxoglutarate + O2
-
Streptomyces clavuligerus clavaminate + succinate + CO2 + H2O
-
?
1.14.11.21 dihydroclavaminate + 2-oxoglutarate + O2 cyclization Streptomyces clavuligerus clavaminate + succinate + CO2 + H2O
-
?
1.14.11.21 additional information specific for 2-oxoglutarate Streptomyces clavuligerus ?
-
?
1.14.11.21 additional information biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor Streptomyces clavuligerus ?
-
?
1.14.11.21 proclavaminate + 2-oxoglutarate + O2
-
Streptomyces clavuligerus dihydroclavaminate + succinate + CO2 + H2O
-
?
1.14.11.21 proclavaminate + 2-oxoglutarate + O2 saturation Streptomyces clavuligerus dihydroclavaminate + succinate + CO2 + H2O
-
?
6.3.3.4 N2-(carboxyethyl)-L-arginine + ATP overview on biological role Streptomyces clavuligerus AMP + diphosphate + deoxyamidinoproclavaminate
-
?

Subunits

EC Number Subunits Comment Organism
6.3.3.4 ? x * 54500, deduced from gene sequence Streptomyces clavuligerus

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.3.4 ATP ATP-binding site Streptomyces clavuligerus