EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.86 | lipopolysaccharide | - |
Homo sapiens | |
3.4.24.86 | phorbol 12-myristate-13-acetate | PMA | Homo sapiens | |
3.4.24.86 | phorbol ester | - |
Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.24.86 | recombinantly expressed human TACE in plasmid transfected chinese hamster ovary cells | Homo sapiens |
EC Number | General Stability | Organism |
---|---|---|
3.4.24.86 | surface-biotinylated TACE is stable in Jurkat cells with a half-life of at least 8h | Homo sapiens |
3.4.24.86 | TACE appears quite stable in untreated cells | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.86 | IC-3 | protects TACE from degradation by inhibiting either TACE itself or another metalloprotease | Homo sapiens | |
3.4.24.86 | TIMP-3 | tissue inhibitor of metalloproteases-3, CAS: 147783-68-4, 171039-15-9, 13037-60-4 | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.24.86 | cell surface | - |
Homo sapiens | 9986 | - |
3.4.24.86 | cytoplasm | - |
Homo sapiens | 5737 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.86 | Homo sapiens | - |
human | - |
3.4.24.86 | Homo sapiens | - |
HeLa cells | - |
3.4.24.86 | Homo sapiens | - |
human monocytic cell line THP-1 | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.24.86 | - |
Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.86 | monocyte | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.86 | beta-amyloid precursor protein + H2O | alpha-secretase processing | Homo sapiens | ? | - |
? | |
3.4.24.86 | L-selectin + H2O | regulates plasma membrane composition and releases soluble signaling molecules and receptors from cells | Homo sapiens | ? | - |
? | |
3.4.24.86 | proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
3.4.24.86 | transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.86 | sheddase | - |
Homo sapiens |