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Literature summary extracted from

  • Doedens, J.R.; Black, R.A.
    Stimulation-induced down-regulation of tumor necrosis factor-alpha converting enzyme (2000), J. Biol. Chem., 275, 14598-14607.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.86 lipopolysaccharide
-
Homo sapiens
3.4.24.86 phorbol 12-myristate-13-acetate PMA Homo sapiens
3.4.24.86 phorbol ester
-
Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.86 recombinantly expressed human TACE in plasmid transfected chinese hamster ovary cells Homo sapiens

General Stability

EC Number General Stability Organism
3.4.24.86 surface-biotinylated TACE is stable in Jurkat cells with a half-life of at least 8h Homo sapiens
3.4.24.86 TACE appears quite stable in untreated cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.86 IC-3 protects TACE from degradation by inhibiting either TACE itself or another metalloprotease Homo sapiens
3.4.24.86 TIMP-3 tissue inhibitor of metalloproteases-3, CAS: 147783-68-4, 171039-15-9, 13037-60-4 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.86 cell surface
-
Homo sapiens 9986
-
3.4.24.86 cytoplasm
-
Homo sapiens 5737
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Homo sapiens
-
human
-
3.4.24.86 Homo sapiens
-
HeLa cells
-
3.4.24.86 Homo sapiens
-
human monocytic cell line THP-1
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.86
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.86 monocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 beta-amyloid precursor protein + H2O alpha-secretase processing Homo sapiens ?
-
?
3.4.24.86 L-selectin + H2O regulates plasma membrane composition and releases soluble signaling molecules and receptors from cells Homo sapiens ?
-
?
3.4.24.86 proTNF-alpha + H2O
-
Homo sapiens soluble TNF-alpha
-
?
3.4.24.86 transforming growth factor alpha + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.86 sheddase
-
Homo sapiens