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Literature summary extracted from

  • Ross, K.E.; Cohen-Fix, O.
    Separase: a conserved protease separating more than just sisters (2002), Trends Cell Biol., 12, 1-3.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.49 securin
-
 Drosophila melanogaster
3.4.22.49 securin activation may be due to separase localization Saccharomyces cerevisiae
3.4.22.49 securin activation may be due to separase localization Schizosaccharomyces pombe

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.49 securin
-
 Drosophila melanogaster
3.4.22.49 securin small protein that binds to and inhibits separase until all pairs of chromatids have established bipolar spindle attachments Homo sapiens
3.4.22.49 securin small protein that binds to and inhibits separase until all pairs of chromatids have established bipolar spindle attachments Saccharomyces cerevisiae
3.4.22.49 securin small protein that binds to and inhibits separase until all pairs of chromatids have established bipolar spindle attachments Schizosaccharomyces pombe

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.22.49 Ca2+ Ca2+-levels affect separase function, C-terminal region contains a Ca2+-binding motif Homo sapiens
3.4.22.49 Ca2+ Ca2+-levels affect separase function, C-terminal region contains a Ca2+-binding motif Saccharomyces cerevisiae
3.4.22.49 Ca2+ Ca2+-levels affect separase function, C-terminal region contains a Ca2+-binding motif Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.49 Scc1 + H2O Homo sapiens
-
 cleaved Scc1
-
 ?
3.4.22.49 Scc1 + H2O Schizosaccharomyces pombe
-
 cleaved Scc1
-
 ?
3.4.22.49 Scc1 + H2O Saccharomyces cerevisiae cleavage at 2 defined sites results in rapid destabilization of Scc1 and its dissociation from chromosomes cleaved Scc1
-
 ?
3.4.22.49 Slk19 + H2O Saccharomyces cerevisiae
-
 cleaved Slk19
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.49 Drosophila melanogaster
-
-
-
3.4.22.49 Homo sapiens
-
-
-
3.4.22.49 Saccharomyces cerevisiae
-
-
-
3.4.22.49 Schizosaccharomyces pombe
-
-
-
3.4.22.49 Xenopus laevis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.49 Scc1 + H2O
-
 Homo sapiens cleaved Scc1
-
 ?
3.4.22.49 Scc1 + H2O
-
 Schizosaccharomyces pombe cleaved Scc1
-
 ?
3.4.22.49 Scc1 + H2O cleavage at 2 defined sites results in rapid destabilization of Scc1 and its dissociation from chromosomes Saccharomyces cerevisiae cleaved Scc1
-
 ?
3.4.22.49 Slk19 + H2O
-
 Saccharomyces cerevisiae cleaved Slk19
-
 ?