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Literature summary extracted from

  • Sagami, H.; Korenaga, T.; Ogura, K.; Steiger, A.; Pyun, H.J.; Coates, R.M.
    Studies on geranylgeranyl diphosphate synthase from rat liver: specific inhibition by 3-azageranylgeranyl diphosphate (1992), Arch. Biochem. Biophys., 297, 314-320.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.29 (E,E,E)-geranylgeranyl diphosphate
-
 Rattus norvegicus
2.5.1.29 (Z,E,E)-Geranylgeranyl diphosphate
-
 Rattus norvegicus
2.5.1.29 3-azageranylgeranyl diphosphate 0.0009 mM, 90% inhibition Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.29 (E,E)-farnesyl diphosphate + isopentenyl diphosphate Rattus norvegicus
-
 geranylgeranyl diphosphate + diphosphate
-
 ?
2.5.1.29 dimethylallyl diphosphate + 3 isopentenyl diphosphate Rattus norvegicus 9% of the activity with farnesyl diphosphate geranylgeranyl diphosphate + 3 diphosphate
-
 ?
2.5.1.29 geranyl diphosphate + 2 isopentenyl diphosphate Rattus norvegicus 15% of the activity with farnesyl diphosphate geranylgeranyl diphosphate + 2 diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.29 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.29 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.29 (E,E)-farnesyl diphosphate + isopentenyl diphosphate
-
 Rattus norvegicus geranylgeranyl diphosphate + diphosphate
-
 ?
2.5.1.29 (E,E)-farnesyl diphosphate + isopentenyl diphosphate
-
 Rattus norvegicus geranylgeranyl diphosphate + diphosphate E,E)-geranylgeranyl diphosphate ?
2.5.1.29 dimethylallyl diphosphate + 3 isopentenyl diphosphate 9% of the activity with farnesyl diphosphate Rattus norvegicus geranylgeranyl diphosphate + 3 diphosphate
-
 ?
2.5.1.29 geranyl diphosphate + 2 isopentenyl diphosphate 15% of the activity with farnesyl diphosphate Rattus norvegicus geranylgeranyl diphosphate + 2 diphosphate
-
 ?