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Literature summary extracted from

  • Klein, R.S.; Lenzi, M.; Lim, T.H.; Hotchkiss, K.A.; Wilson, P.; Schwartz, E.L.
    Novel 6-substituted uracil analogs as inhibitors of the angiogenic actions of thymidine phosphorylase (2001), Biochem. Pharmacol., 62, 1257-1263.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.4
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.4 6-(2-aminoethyl)amine-5-chlorouracil AEAC Homo sapiens
2.4.2.4 additional information 5- and 6-substituted uracil analogs Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.4 additional information Homo sapiens angiogenic activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 additional information angiogenic activity Homo sapiens ?
-
 ?
2.4.2.4 thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.4 7.8
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.4 0.000165
-
 6-(2-aminoethyl)amine-5-chlorouracil
-
 Homo sapiens