Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Veres, Z.; Neszmelyi, A.; Szabolcs, A.; Denes, G.
    Inhibition of uridine phosphorylase by pyrimidine nucleoside analogs and consideration of substrate binding to the enzyme based on solution conformation as seen by NMR spectroscopy (1988), Eur. J. Biochem., 178, 173-181.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.3 2',3'-Dideoxy-5-ethyluridine
-
Rattus norvegicus
2.4.2.3 2'-deoxylyxofuranosyl-5-ethyluracil
-
Rattus norvegicus
2.4.2.3 2,2'-Anhydro-5-ethyluridine
-
Rattus norvegicus
2.4.2.3 2,3'-Anhydro-2'-deoxy-5-ethyluridine
-
Rattus norvegicus
2.4.2.3 2,5'-Anhydro-2'-deoxy-5-ethyluridine
-
Rattus norvegicus
2.4.2.3 3'-Azido-2',3'-dideoxy-5-ethyluridine
-
Rattus norvegicus
2.4.2.3 3'-Azido-2',3'-dideoxy-5-methyluridine
-
Rattus norvegicus
2.4.2.3 3'-Bromo-2',3'-dideoxy-5-ethyluridine
-
Rattus norvegicus
2.4.2.3 3'-Chloro-2',3'-dideoxy-5-ethyluridine
-
Rattus norvegicus
2.4.2.3 3'-Chloro-2',3'-dideoxy-5-methyluridine
-
Rattus norvegicus
2.4.2.3 3'-O-Acetyl-2,2'-anhydro-5-ethyluridine
-
Rattus norvegicus
2.4.2.3 Arabinofuranosyl-5-ethyluracil
-
Rattus norvegicus
2.4.2.4 2',3'-Dideoxy-5-ethyluridine 9% inhibition at 10 mM Rattus norvegicus
2.4.2.4 3'-Azido-2',3'-dideoxy-5-ethyluridine 16% inhibition at 10 mM Rattus norvegicus
2.4.2.4 3'-Azido-2',3'-dideoxy-5-methyluridine 6% inhibition at 10 mM Rattus norvegicus
2.4.2.4 3'-Bromo-2',3'-dideoxy-5-ethyluridine 9% inhibition at 5 mM Rattus norvegicus
2.4.2.4 3'-Chloro-2',3'-dideoxy-5-ethyluridine 26% inhibition at 10 mM Rattus norvegicus
2.4.2.4 3'-Chloro-2',3'-dideoxy-5-methyluridine 18% inhibition at 10 mM Rattus norvegicus
2.4.2.4 Arabinofuranosyl-5-ethyluracil 10% inhibition at 10 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.3 Rattus norvegicus
-
-
-
2.4.2.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.3 intestinal mucosa
-
Rattus norvegicus
-
2.4.2.4 intestinal mucosa
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.3 arabinofuranosyl-5-ethyluracil + phosphate weak substrate Rattus norvegicus 5-ethyluracil + arabinose-1-phosphate
-
?
2.4.2.3 additional information no substrates: 3'-azido-2',3'-dideoxy-5-methyluridine, 3'-azido-2',3'-dideoxy-5-ethyluridine, 2',3'-dideoxy-5-ethyluridine, 3'-chloro-2',3'-dideoxy-5-ethyluridine, 3'-chloro-2',3'-dideoxy-5-methyluridine, 3'-bromo-2',3'-dideoxy-5-ethyluridine, 2'-deoxylyxofuranosyl-5-ethyluracil, 3'-O-acetyl-2,2'-anhydro-5-ethyluridine, 2,3'-anhydro-2'-deoxy-5-ethyluridine, 2,5'-anhydro-2'-deoxy-5-ethyluridine Rattus norvegicus ?
-
?
2.4.2.4 thymidine + phosphate
-
Rattus norvegicus thymine + 2-deoxy-D-ribose 1-phosphate
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.3 0.056
-
3'-Azido-2',3'-dideoxy-5-methyluridine
-
Rattus norvegicus
2.4.2.3 0.107
-
Arabinofuranosyl-5-ethyluracil
-
Rattus norvegicus
2.4.2.3 0.109
-
2',3'-Dideoxy-5-ethyluridine
-
Rattus norvegicus
2.4.2.3 0.21
-
3'-Chloro-2',3'-dideoxy-5-ethyluridine
-
Rattus norvegicus
2.4.2.3 0.225
-
3'-Azido-2',3'-dideoxy-5-ethyluridine
-
Rattus norvegicus
2.4.2.3 0.361
-
3'-Chloro-2',3'-dideoxy-5-methyluridine
-
Rattus norvegicus
2.4.2.3 0.448
-
3'-Bromo-2',3'-dideoxy-5-ethyluridine
-
Rattus norvegicus
2.4.2.3 1.003
-
2'-deoxylyxofuranosyl-5-ethyluracil
-
Rattus norvegicus