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Literature summary extracted from

  • el Kouni, M.H.; el Kouni, M.M.; Naguib, F.N.
    Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines (1993), Cancer Res., 53, 3687-3693.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.3 Benzylacyclouridines 0.1 mM Homo sapiens
2.4.2.3 Benzylacyclouridines 0.1 mM Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.3 additional information
-
 additional information
-
 Mus musculus
2.4.2.3 additional information
-
 additional information
-
 Homo sapiens
2.4.2.4 additional information
-
 additional information
-
 Mus musculus
2.4.2.4 additional information
-
 additional information
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.3 Homo sapiens
-
-
-
2.4.2.3 Mus musculus
-
-
-
2.4.2.4 Homo sapiens
-
-
-
2.4.2.4 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.3
-
 Mus musculus
2.4.2.3
-
 Homo sapiens
2.4.2.4
-
 Mus musculus
2.4.2.4
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.3 liver
-
 Mus musculus
-
2.4.2.3 liver
-
 Homo sapiens
-
2.4.2.3 placenta
-
 Homo sapiens
-
2.4.2.4 liver
-
 Mus musculus
-
2.4.2.4 liver
-
 Homo sapiens
-
2.4.2.4 placenta
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.4 additional information
-
-
 Mus musculus
2.4.2.4 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.3 5'-deoxy-5-fluorouridine + phosphate 25% of the activity with uridine Mus musculus 5-fluorouracil + 5-deoxyribose-1-phosphate
-
 ?
2.4.2.3 5-fluoro-2'-deoxyuridine + phosphate 15% of the activity with uridine Mus musculus 5-fluorouracil + 2-deoxyribose-1-phosphate
-
 ?
2.4.2.3 5-fluorouridine + phosphate 15% of the activity with uridine Homo sapiens 5-fluorouracil + alpha-D-ribose-1-phosphate
-
 ?
2.4.2.3 5-fluorouridine + phosphate 85% of the activity with uridine Mus musculus 5-fluorouracil + alpha-D-ribose-1-phosphate
-
 ?
2.4.2.3 additional information
-
 Mus musculus ?
-
 ?
2.4.2.3 additional information no substrates are: thymidine, deoxyuridine, fluorodeoxyuridiune, 5'-deoxyfluorouridine Homo sapiens ?
-
 ?
2.4.2.3 uridine + phosphate liver enzyme is highly specific to uridine Homo sapiens uracil + alpha-D-ribose 1-phosphate
-
 ?
2.4.2.3 uridine + phosphate broader specificity than human enzyme Mus musculus uracil + alpha-D-ribose 1-phosphate
-
 ?
2.4.2.4 5'-deoxy-5-fluorouridine + phosphate
-
 Homo sapiens 5-fluorouracil + 5-deoxyribose-1-phosphate
-
 ?
2.4.2.4 5-fluoro-2'-deoxyuridine + phosphate
-
 Homo sapiens 5-fluorouracil + 2-deoxyribose-1-phosphate
-
 ?
2.4.2.4 5-fluorouridine + phosphate
-
 Homo sapiens 5-fluorouracil + ribose 1-phosphate
-
 ?
2.4.2.4 thymidine + phosphate
-
 Mus musculus thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?
2.4.2.4 thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?