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Literature summary extracted from

  • Sugata, S.; Kono, A.; Hara, Y.; Karube, Y.; Matsushima, Y.
    Partial purification of a thymidine phosphorylase from human gastric cancer (1986), Chem. Pharm. Bull., 34, 1219-1222.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.4 0.168
-
 thymidine
-
 Homo sapiens
2.4.2.4 1.72
-
 5'-deoxy-5-fluorouridine
-
 Homo sapiens
2.4.2.4 13.3
-
 1-(Tetrahydro-2-furanyl)-5-fluorouracil
-
 Homo sapiens
2.4.2.4 47.6
-
 uridine
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.4 partial Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.4 gastrointestinal cancer cell poorly differentiated adenocarcinoma Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.4 1-(tetrahydro-2-furanyl)-5-fluorouracil + phosphate i.e. Tegafur Homo sapiens ?
-
 ?
2.4.2.4 5'-deoxy-5-fluorouridine + phosphate 5'-DFUR Homo sapiens 5-fluorouracil + 5-deoxyribose-1-phosphate
-
 ?
2.4.2.4 additional information the phosphorolytic acitvities towards thymidine, 5'-deoxy-5-fluorouridine and 1-(tetrahydro-2-furanyl)-5-fluorouracil remain closely parallel during purification Homo sapiens ?
-
 ?