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Literature summary extracted from

  • Kudo, T.; Iwai, T.; Kubota, T.; Iwasaki, H.; Takayma, Y.; Hiruma, T.; Inaba, N.; Zhang, Y.; Gotoh, M.; Togayachi, A.; Narimatsu, H.
    Molecular cloning and characterization of a novel UDP-Gal:GalNAcalpha peptide beta1,3-galactosyltransferase (C1Gal-T2), an enzyme synthesizing a core 1 structure of O-glycan (2002), J. Biol. Chem., 277, 47724-47731.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.122 DNA sequence determination, functional expression in human LSC cells Homo sapiens
2.4.1.122 functional expression in human LSC cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.122 microsome
-
 Homo sapiens
-
-
2.4.1.122 additional information type II transmembrane protein Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.122 UDP-galactose + glycoprotein N-acetyl-D-galactosamine Homo sapiens enzyme is important in O-glycan biosynthesis in digestive organs UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.122 Homo sapiens
-
-
-
2.4.1.122 Homo sapiens Q96EU7 form 2
-
2.4.1.122 Homo sapiens Q9NS00 form 1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.122 kidney
-
 Homo sapiens
-
2.4.1.122 additional information no endogenous activity in Jurkat and LSC, a colorectal cell line, cells Homo sapiens
-
2.4.1.122 salivary gland
-
 Homo sapiens
-
2.4.1.122 small intestine low content Homo sapiens
-
2.4.1.122 spleen
-
 Homo sapiens
-
2.4.1.122 stomach
-
 Homo sapiens
-
2.4.1.122 testis
-
 Homo sapiens
-
2.4.1.122 thymus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.122 UDP-galactose + glycoprotein N-acetyl-D-galactosamine
-
 Homo sapiens UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?
2.4.1.122 UDP-galactose + glycoprotein N-acetyl-D-galactosamine
-
 Homo sapiens UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine i.e. core 1 structure ?
2.4.1.122 UDP-galactose + glycoprotein N-acetyl-D-galactosamine enzyme is important in O-glycan biosynthesis in digestive organs Homo sapiens UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?
2.4.1.122 UDP-galactose + p-nitrophenyl-beta-N-acetylgalactosamide
-
 Homo sapiens UDP + beta-D-galactosyl-1,3-N-acetylgalactosyl-p-nitrophenyl
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.122 37
-
 assay at Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.4.1.122 6.5 7.4 assays at Homo sapiens