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Literature summary extracted from

  • Brockhausen, I.; M๖ller, G.; Pollex-Kruger, A.; Rutz, V.; Paulsen, H.; Matta, K.L.
    Control of O-glycan synthesis: specificity and inhibition of O-glycan core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 3-galactosyltransferase from rat liver (1992), Biochem. Cell Biol., 70, 99-108.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.122 6-O-(4,4-azo)phenyl-GalNAc-alpha-benzyl
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.122 UDP-galactose + glycoprotein N-acetyl-D-galactosamine Rattus norvegicus major control factor in the biosynthesis of O-glycans UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.122 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.122 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.122 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.122 UDP-galactose + glycoprotein N-acetyl-D-galactosamine glycosyl acceptor specificity study Rattus norvegicus UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?
2.4.1.122 UDP-galactose + glycoprotein N-acetyl-D-galactosamine major control factor in the biosynthesis of O-glycans Rattus norvegicus UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
-
 ?
2.4.1.122 UDP-galactose + N-acetyl-alpha-D-galactosaminyl-benzyl removal or substitution of the 3-OH group or removal of the 4-OH group abolishes enzyme activity, removal or substitution of the 6-OH reduces activity slightly leading to competititve substrates Rattus norvegicus UDP + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-benzyl
-
 ?
2.4.1.122 UDP-galactose + N-acetylgalactosaminide mucin
-
 Rattus norvegicus UDP + beta-D-galactosyl-1,3-N-acetylgalactosaminide mucin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.122 UDP-Gal:N-acetylgalactosaminide mucin:beta1,3-galactosyltransferase
-
 Rattus norvegicus