Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Koya, D.; Dennis, J.W.; Warren, C.E.; Takahara, N.; Schoen, F.J.; Nishio, Y.; Nakajima, T.; Lipes, M.A.; King, G.L.
    Overexpression of core 2 N-acetylglycosaminyltransferase enhances cytokine actions and induces hypertrophic myocardium in transgenic mice (1999), FASEB J., 13, 2329-2337.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.102 expression in PC12 cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.102 additional information construction of transgenic mice by microinjection of rat cDNA fused to a rat cardiac-specific promotor into pronuclei of fertilized FVB mouse eggs, overexpression and increase of enzyme activity in the heart leading to cardiac hypertrophy, elevated content of sialylated O-glycans, induction of c-fos expression, and phenotypic changes Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.102 additional information Mus musculus enzyme is developmentally regulated, increased activity in hearts of diabetic organisms, regulation by hyperglycemia and insulin ?
-
 ?
2.4.1.102 additional information Rattus norvegicus enzyme is developmentally regulated, increased activity in hearts of diabetic organisms, regulation by hyperglycemia and insulin ?
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R Mus musculus involved in regulation of downstream intracellular signal transduction pathways UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R Mus musculus involved in the development of cardiomyopathy UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R Mus musculus involved in biosynthesis of O-glycans core class 2 UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R Rattus norvegicus involved in biosynthesis of O-glycans core class 2 UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.102 Mus musculus
-
-
-
2.4.1.102 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.102 recombinant as GST fusion protein from a bacterial expression system Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.102 heart
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.102 additional information enzyme is developmentally regulated, increased activity in hearts of diabetic organisms, regulation by hyperglycemia and insulin Mus musculus ?
-
 ?
2.4.1.102 additional information enzyme is developmentally regulated, increased activity in hearts of diabetic organisms, regulation by hyperglycemia and insulin Rattus norvegicus ?
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R
-
 Mus musculus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R
-
 Rattus norvegicus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R involved in regulation of downstream intracellular signal transduction pathways Mus musculus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R involved in the development of cardiomyopathy Mus musculus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R involved in biosynthesis of O-glycans core class 2 Mus musculus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R involved in biosynthesis of O-glycans core class 2 Rattus norvegicus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.102 core 2 GlcNAc-T
-
 Mus musculus
2.4.1.102 core 2 GlcNAc-T
-
 Rattus norvegicus