Literature summary extracted from

Nakamura, M.; Kudo, T.; Narimatsu, H.; Furukawa, Y.; Kikuchi, J.; Asakura, S.; Yang, W.; Iwase, S.; Hatake, K.; Miura, Y.
Single glycosyltransferase, core 2 beta1-6-N-acetylglucosaminyltransferase, regulates cell surface sialyl-Lex expression level in human pre-B lymphocytic leukemia cell line KM3 treated with phorbolester (1998), J. Biol. Chem., 273, 26779-26789.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.4.1.102	overexpression in KM3 leukemia cell line	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.4.1.102	12-O-tetradecanoylphorbol-13-acetate	about 10fold decreased activity, down-regulation of native enzyme in KM3 leukemia cell line, but not of the recombinant enzyme; i.e. TPA	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.1.102	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.4.1.102	acute myeloid leukemia cell	-	Homo sapiens	-
2.4.1.102	KM-3 cell	pre-B lymphocytic leukemia cell line	Homo sapiens	-

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
2.4.1.102	0.0000056	-	untreated recombinant KM3 leukemia cell line	Homo sapiens

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.1.102	UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R	-	Homo sapiens	UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R	i.e. core class 2	?

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Release 2023.1 (January 2023)