Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Henion, T.R.; Zhou, D.; Wolfer, D.P.; Jungalwala, F.B.; Hennet, T.
    Cloning of a mouse beta1,3 N-acetylglucosaminyltransferase GlcNAc(beta1,3)Gal(beta1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis (2001), J. Biol. Chem., 276, 30261-30269.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.206 DNA and amino acid sequence determination, functional expression in Spodoptera frugiperda Sf9 cells via baculovirus infection Homo sapiens
2.4.1.206 DNA sequence determination, functional expression in Spodoptera frugiperda Sf9 cells via baculovirus infection Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.206 membrane
-
 Mus musculus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.206 Homo sapiens Q9BYG0
-
-
2.4.1.206 Mus musculus Q8BGY6
-
-
2.4.1.206 no activity in Spodoptera frugiperda
-
 Sf9 cells
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.206 B-lymphocyte splenic Mus musculus
-
2.4.1.206 brain
-
 Homo sapiens
-
2.4.1.206 brain low content Mus musculus
-
2.4.1.206 brain expression during embryonic brain development Mus musculus
-
2.4.1.206 cerebellar Purkinje cell
-
 Mus musculus
-
2.4.1.206 cerebellum distinct cellular layers: Purkinje cell layer, molecular cell layer, granule cell layer + white matter Mus musculus
-
2.4.1.206 embryo expression during mouse development Mus musculus
-
2.4.1.206 lung low content Mus musculus
-
2.4.1.206 placenta
-
 Mus musculus
-
2.4.1.206 spleen
-
 Mus musculus
-
2.4.1.206 thymus low content Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.206 0.00121
-
 recombinant enzyme, substrate lactosylceramide Homo sapiens
2.4.1.206 0.00121
-
 recombinant enzyme, substrate lactosylceramide Mus musculus
2.4.1.206 0.00123
-
 recombinant enzyme, substrate lD-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide Homo sapiens
2.4.1.206 0.00123
-
 recombinant enzyme, substrate lD-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide Mus musculus
2.4.1.206 0.00174
-
 recombinant enzyme, substrate D-galactosyl-1,4-beta-N-acetyl-D-galactosaminyl-1,3-beta-(sialyl-alpha-2,3)-D-galactosyl-1,4-beta-D-glucosylceramide Homo sapiens
2.4.1.206 0.00174
-
 recombinant enzyme, substrate D-galactosyl-1,4-beta-N-acetyl-D-galactosaminyl-1,3-beta-(sialyl-alpha-2,3)-D-galactosyl-1,4-beta-D-glucosylceramide Mus musculus
2.4.1.206 0.0021
-
 recombinant enzyme, substrate D-galactosyl-1,4-beta-N-acetyl-D-galactosaminyl-1,3-beta-(sialyl-alpha-2,8-sialyl-alpha-2,3)-D-galactosyl-1,4-beta-D-glucosylceramide Homo sapiens
2.4.1.206 0.0021
-
 recombinant enzyme, substrate D-galactosyl-1,4-beta-N-acetyl-D-galactosaminyl-1,3-beta-(sialyl-alpha-2,8-sialyl-alpha-2,3)-D-galactosyl-1,4-beta-D-glucosylceramide Mus musculus
2.4.1.206 0.00254
-
 recombinant enzyme, substrate D-galactosyl-1,4-beta-N-acetyl-D-galactosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide Homo sapiens
2.4.1.206 0.00254
-
 recombinant enzyme, substrate D-galactosyl-1,4-beta-N-acetyl-D-galactosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.206 UDP-N-acetyl-D-glucosamine + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-1,4-beta-(sialyl-alpha-2,3)-D-galactosyl-1,4-beta-D-glucosylceramide
-
 Homo sapiens UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-1,4-beta-(sialyl-alpha-2,3)-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.1.206 UDP-N-acetyl-D-glucosamine + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-1,4-beta-(sialyl-alpha-2,3)-D-galactosyl-1,4-beta-D-glucosylceramide
-
 Mus musculus UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-1,4-beta-(sialyl-alpha-2,3)-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.1.206 UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-D-glucosylceramide best substrate Homo sapiens UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.1.206 UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-D-glucosylceramide best substrate Mus musculus UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.1.206 UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-D-glucosylceramide acceptor substrate specificity, overview Homo sapiens UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.1.206 UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-D-glucosylceramide acceptor substrate specificity, overview Mus musculus UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.1.206 UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-N-acetyl-D-galactosaminyl-1,3-beta-(sialyl-alpha-2,8-sialyl-alpha-2,3)-D-galactosyl-1,4-beta-D-glucosylceramide
-
 Homo sapiens UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-N-acetyl-D-galactosaminyl-1,3-beta-(sialyl-alpha-2,8-sialyl-alpha-2,3)-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.1.206 UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-N-acetyl-D-galactosaminyl-1,3-beta-(sialyl-alpha-2,8-sialyl-alpha-2,3)-D-galactosyl-1,4-beta-D-glucosylceramide
-
 Mus musculus UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-N-acetyl-D-galactosaminyl-1,3-beta-(sialyl-alpha-2,8-sialyl-alpha-2,3)-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.1.206 UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-N-acetyl-D-galactosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 Homo sapiens UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-N-acetyl-D-galactosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.1.206 UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-N-acetyl-D-galactosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 Mus musculus UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-N-acetyl-D-galactosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.1.206 UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 Homo sapiens UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.1.206 UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 Mus musculus UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.206 beta1,3 N-acetylglucosaminyltransferase GlcNAc(beta1,3)Gal(beta1,4)Glc-ceramide synthase
-
 Homo sapiens
2.4.1.206 beta1,3 N-acetylglucosaminyltransferase GlcNAc(beta1,3)Gal(beta1,4)Glc-ceramide synthase
-
 Mus musculus