Literature summary extracted from

Joe, Y.A.; Wolff, E.C.; Lee, Y.B.; Park, M.H.
Enzyme-substrate intermediate at a specific lysine residue is required for deoxyhypusine synthesis. The role of Lys329 in human deoxyhypusine synthase (1997), J. Biol. Chem., 272, 32679-32685.

Protein Variants

EC Number	Protein Variants	Comment	Organism
2.5.1.46	H288A	6% of wild-type activity	Homo sapiens
2.5.1.46	K329R	no activity	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.46	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.46	[eIF5A-precursor]-lysine + spermidine	-	Homo sapiens	[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine	i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.5.1.46	NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)