Literature summary extracted from

Danzin, C.; Cardinaud, R.
Deoxyribosyl transfer catalysis with trans-N-deoxyribosylase. Kinetic study of purine(pyrimidine) to pyrimidine(purine) trans-N-deoxyribosylase (1976), Eur. J. Biochem., 62, 365-372.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.4.2.6	adenine	-	Lactobacillus helveticus
2.4.2.6	cytosine	-	Lactobacillus helveticus
2.4.2.6	deoxyadenosine	linear competitive inhibition of deoxycytidine	Lactobacillus helveticus
2.4.2.6	deoxycytidine	-	Lactobacillus helveticus

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.4.2.6	0.0073	-	adenine	reaction with deoxyinosine	Lactobacillus helveticus
2.4.2.6	0.008	-	adenine	reaction with deoxyguanosine	Lactobacillus helveticus
2.4.2.6	0.019	-	adenine	reaction with deoxycytidine	Lactobacillus helveticus
2.4.2.6	0.021	-	adenine	reaction with deoxyadenosine	Lactobacillus helveticus
2.4.2.6	0.073	-	cytosine	reaction with deoxyinosine	Lactobacillus helveticus
2.4.2.6	0.077	-	cytosine	reaction with deoxyguanosine	Lactobacillus helveticus
2.4.2.6	0.09	-	deoxycytidine	reaction with adenine	Lactobacillus helveticus
2.4.2.6	0.092	-	deoxyadenosine	reaction with adenine	Lactobacillus helveticus
2.4.2.6	0.095	-	deoxycytidine	reaction with cytosine	Lactobacillus helveticus
2.4.2.6	0.12	-	deoxyadenosine	reaction with cytosine	Lactobacillus helveticus
2.4.2.6	0.17	-	cytosine	reaction with deoxycytidine	Lactobacillus helveticus
2.4.2.6	0.22	-	cytosine	reaction with deoxyadenosine	Lactobacillus helveticus
2.4.2.6	0.346	-	deoxyguanosine	reaction with adenine	Lactobacillus helveticus
2.4.2.6	0.37	-	deoxyguanosine	reaction with cytosine	Lactobacillus helveticus
2.4.2.6	3.4	-	deoxyinosine	reaction with adenine	Lactobacillus helveticus
2.4.2.6	3.5	-	deoxyinosine	reaction with cytosine	Lactobacillus helveticus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.2.6	Lactobacillus helveticus	-	-	-

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
2.4.2.6	2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1	ping-pong bi bi mechanism	Lactobacillus helveticus	a

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
2.4.2.6	0.8	-	reaction with deoxyinosine and adenine	Lactobacillus helveticus
2.4.2.6	7.75	-	reaction with thymidine and cytosine	Lactobacillus helveticus
2.4.2.6	43	-	reaction with deoxycytidine and adenine	Lactobacillus helveticus

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.2.6	deoxyadenosine + adenine	-	Lactobacillus helveticus	adenine + deoxyadenosine	-	?
2.4.2.6	deoxyadenosine + cytosine	-	Lactobacillus helveticus	adenine + deoxycytidine	-	r
2.4.2.6	deoxycytidine + adenine	-	Lactobacillus helveticus	cytosine + deoxyadenosine	-	r
2.4.2.6	deoxyguanosine + adenine	-	Lactobacillus helveticus	guanine + deoxyadenosine	-	?
2.4.2.6	deoxyguanosine + cytosine	-	Lactobacillus helveticus	guanine + deoxycytidine	-	r
2.4.2.6	deoxyinosine + adenine	-	Lactobacillus helveticus	hypoxanthine + deoxyadenosine	-	r
2.4.2.6	deoxyinosine + cytosine	-	Lactobacillus helveticus	hypoxanthine + deoxycytidine	-	?
2.4.2.6	thymidine + cytosine	-	Lactobacillus helveticus	thymine + 2'-deoxycytidine	-	?

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
2.4.2.6	0.021	-	adenine	-	Lactobacillus helveticus
2.4.2.6	0.092	-	deoxyadenosine	-	Lactobacillus helveticus
2.4.2.6	0.095	-	deoxycytidine	-	Lactobacillus helveticus
2.4.2.6	0.17	-	cytosine	-	Lactobacillus helveticus

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Release 2023.1 (January 2023)