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Literature summary extracted from

  • Rankin, P.W.; Jacobson, E.L.; benjamin, R.C.; Moss, J.; Jacobson, M.K.
    Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo (1989), J. Biol. Chem., 264, 4312-4317.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.30 1-methylnicotinamide chloride IC50: 1.7 mM Bos taurus
2.4.2.30 2-Aminobenzamide IC50: 0.1 mM Bos taurus
2.4.2.30 3-aminobenzamide IC50: 0.0054 Bos taurus
2.4.2.30 3-isobutyl-1-methylxanthine IC50: 3.1 mM Bos taurus
2.4.2.30 3-Methoxybenzamide IC50: 0.0034 mM Bos taurus
2.4.2.30 4-Aminobenzamide IC50: 0.4 mM Bos taurus
2.4.2.30 5-bromodeoxyuridine IC50: 0.015 mM Bos taurus
2.4.2.30 5-Methylnicotinamide IC50: 0.07 Bos taurus
2.4.2.30 8-Methylnicotinamide IC50: 7.8 mM Bos taurus
2.4.2.30 Benzamide IC50: 0.0033 mM Bos taurus
2.4.2.30 Caffeine IC50: 1.4 mM Bos taurus
2.4.2.30 hypoxanthine IC50: 1.7 mM Bos taurus
2.4.2.30 Isonicotinate hydrazide IC50: 4.8 MM Bos taurus
2.4.2.30 nicotinamide IC50: 0.031 mM Bos taurus
2.4.2.30 Pyrazinamide IC50: 0.13 mM Bos taurus
2.4.2.30 Theobromine IC50: 0.11 mM Bos taurus
2.4.2.30 theophylline IC50: 0.0046 Bos taurus
2.4.2.30 thymidine IC50: 0.043 Bos taurus
2.4.2.30 Zn2+ ZnCl2, IC50: 0.077 mM Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Bos taurus
-
 calf
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.30 thymus
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Bos taurus nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.2.30 0.0033
-
 IC50: 0.0033 mM Bos taurus Benzamide
2.4.2.30 0.0034
-
 IC50: 0.0034 mM Bos taurus 3-Methoxybenzamide
2.4.2.30 0.0054
-
 IC50: 0.0054 Bos taurus 3-aminobenzamide
2.4.2.30 0.015
-
 IC50: 0.015 mM Bos taurus 5-bromodeoxyuridine
2.4.2.30 0.031
-
 IC50: 0.031 mM Bos taurus nicotinamide
2.4.2.30 0.043
-
 IC50: 0.043 mM Bos taurus thymidine
2.4.2.30 0.046
-
 IC50: 0.046 mM Bos taurus theophylline
2.4.2.30 0.07
-
 IC50: 0.07 mM Bos taurus 5-Methylnicotinamide
2.4.2.30 0.077
-
 ZnCl2, IC50: 0.077 mM Bos taurus Zn2+
2.4.2.30 0.1
-
 IC50: 0.1 mM Bos taurus 2-Aminobenzamide
2.4.2.30 0.11
-
 IC50: 0.11 mM Bos taurus Theobromine
2.4.2.30 0.13
-
 IC50: 0.13 mM Bos taurus Pyrazinamide
2.4.2.30 0.4
-
 IC50: 0.4 mM Bos taurus 4-Aminobenzamide
2.4.2.30 1.4
-
 IC50: 1.4 mM Bos taurus Caffeine
2.4.2.30 1.7
-
 IC50: 1.7 mM Bos taurus hypoxanthine
2.4.2.30 1.7
-
 IC50: 1.7 mM Bos taurus 1-methylnicotinamide chloride
2.4.2.30 3.1
-
 IC50: 3.1 mM Bos taurus 3-isobutyl-1-methylxanthine
2.4.2.30 4.8
-
 IC50: 4.8 mM Bos taurus Isonicotinate hydrazide
2.4.2.30 7.8
-
 IC50: 7.8 mM Bos taurus 8-Methylnicotinamide