EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.4.2.30 | DNA | absolute requirement | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.2.30 | 3-aminobenzamide | 1 mM, 99% inhibition | Homo sapiens | |
2.4.2.30 | 3-aminobenzoic acid | 1 mM, 12% inhibition | Homo sapiens | |
2.4.2.30 | Cu2+ | - |
Homo sapiens | |
2.4.2.30 | Hg2+ | - |
Homo sapiens | |
2.4.2.30 | nicotinamide | 1 mM, 93% inhibition | Homo sapiens | |
2.4.2.30 | PCMB | complete | Homo sapiens | |
2.4.2.30 | Zn2+ | - |
Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.4.2.30 | Ba2+ | enhances activity | Homo sapiens | |
2.4.2.30 | Mg2+ | enhances both the automodification and poly(ADP-ribosyl)ation of histone H1 | Homo sapiens | |
2.4.2.30 | Sr2+ | enhances activity | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.4.2.30 | 116000 | - |
1 * 116000, SDS-PAGE | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.2.30 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.4.2.30 | - |
Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.2.30 | placenta | - |
Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.4.2.30 | 1.02 | - |
- |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.30 | NAD+ + (ADP-D-ribosyl)n-acceptor | poly(ADP-ribosyl)ation of histone H1 | Homo sapiens | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
2.4.2.30 | NAD+ + (ADP-D-ribosyl)n-acceptor | catalyzes poly(ADP-ribosyl)ation of the synthetase itself, automodification | Homo sapiens | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.4.2.30 | monomer | 1 * 116000, SDS-PAGE | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.4.2.30 | 8.5 | - |
reaction with histone in presence of DNA, 0.1 M glycine-NaOH buffer | Homo sapiens |
2.4.2.30 | 8.7 | - |
reaction with histone in presence of DNA, 0.1 M Tris-HCl buffer | Homo sapiens |