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Literature summary extracted from

  • Iber, H.; van Echten, G.; Sandhoff, K.
    Substrate specificity of alpha 2->3-sialyltransferases in ganglioside biosynthesis of rat liver Golgi (1991), Eur. J. Biochem., 195, 115-120.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.3.2 Triton CF-54 activation Rattus norvegicus
2.4.3.2 Triton X-100 slight activation Rattus norvegicus
2.4.3.8 Triton CF-54
-
 Rattus norvegicus
2.4.3.9 Triton CF-54 inhibits at higher concentrations Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.3.2 ganglioside GM3 in the presence of Triton CF-54 Rattus norvegicus
2.4.3.2 lactosylceramide inhibits reaction with GM1a Rattus norvegicus
2.4.3.9 ganglioside GM1a
-
 Rattus norvegicus
2.4.3.9 Triton CF-54 at higher concentrations Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.3.9 0.068
-
 lactosylceramide
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.3.2 Golgi apparatus
-
 Rattus norvegicus 5794
-
2.4.3.8 Golgi apparatus
-
 Rattus norvegicus 5794
-
2.4.3.9 Golgi apparatus
-
 Rattus norvegicus 5794
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.2 Rattus norvegicus
-
-
-
2.4.3.8 Rattus norvegicus
-
-
-
2.4.3.9 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.2 liver
-
 Rattus norvegicus
-
2.4.3.8 liver
-
 Rattus norvegicus
-
2.4.3.9 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.2 CMP-N-acetyl-beta-neuraminate + ganglioside GA1
-
 Rattus norvegicus CMP + ganglioside GM1b
-
 ?
2.4.3.2 CMP-N-acetyl-beta-neuraminate + ganglioside GD1b
-
 Rattus norvegicus CMP + ganglioside GT1b
-
 ?
2.4.3.2 CMP-N-acetyl-beta-neuraminate + ganglioside GM1a
-
 Rattus norvegicus CMP + ganglioside GD1a i.e. ganglioside GD1a ?
2.4.3.8 CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 Rattus norvegicus CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
2.4.3.9 CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 Rattus norvegicus CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide i.e. ganglioside GM3 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.3.8 37
-
 assay at Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.4.3.2 56
-
 t1/2: 60 s Rattus norvegicus
2.4.3.8 56
-
 20% loss of activity after 120 s Rattus norvegicus
2.4.3.9 56
-
 t1/2: 60 s Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.3.2 additional information
-
 additional information
-
 Rattus norvegicus