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Literature summary extracted from

  • Busam, K.; Decker, K.
    Ganglioside biosynthesis in rat liver. Characterization of three sialyltransferases (1986), Eur. J. Biochem., 160, 23-30.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.3.2 Triton X-100 activation Rattus norvegicus
2.4.3.8 Triton X-100
-
Rattus norvegicus
2.4.3.9 Triton X-100 activation Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.3.2 Ba2+ 10 mM BaCl2, 12% inhibition Rattus norvegicus
2.4.3.2 Ca2+ 10 mM CaCl2, 39% inhibition Rattus norvegicus
2.4.3.2 Cd2+ 10 mM CdCl2, 85% inhibition Rattus norvegicus
2.4.3.2 Co2+ 10 mM CoCl2, 44% inhibition Rattus norvegicus
2.4.3.2 Cu2+ 10 mM CuCl2, complete inhibition Rattus norvegicus
2.4.3.2 Ni2+ 10 mM NiCl2, 75% inhibition Rattus norvegicus
2.4.3.2 Zn2+ 10 mM ZnCl2, 10% inhibition Rattus norvegicus
2.4.3.8 Ba2+ weak Rattus norvegicus
2.4.3.8 Ca2+
-
Rattus norvegicus
2.4.3.8 Cd2+ strong Rattus norvegicus
2.4.3.8 Co2+
-
Rattus norvegicus
2.4.3.8 Cu2+ strong Rattus norvegicus
2.4.3.8 EDTA not Rattus norvegicus
2.4.3.8 additional information IAA, 2-mercaptoethanol Rattus norvegicus
2.4.3.8 Ni2+
-
Rattus norvegicus
2.4.3.8 Zn2+ weak Rattus norvegicus
2.4.3.9 Ba2+ weak Rattus norvegicus
2.4.3.9 Ca2+ weak Rattus norvegicus
2.4.3.9 Cd2+ strong Rattus norvegicus
2.4.3.9 Co2+
-
Rattus norvegicus
2.4.3.9 Cu2+ strong Rattus norvegicus
2.4.3.9 Mn2+ weak Rattus norvegicus
2.4.3.9 additional information not inhibited by EDTA; not inhibited by Fe2+, Mg2+, IAA, 2-mercaptoethanol Rattus norvegicus
2.4.3.9 Ni2+ strong Rattus norvegicus
2.4.3.9 Zn2+ weak Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.3.2 0.5
-
CMP-N-acetyl-beta-neuraminate pH 6.4, 37°C, reaction with ganglioside GM1 Rattus norvegicus
2.4.3.2 0.5
-
ganglioside GM1a pH 6.4, 37°C Rattus norvegicus
2.4.3.8 0.1
-
ganglioside GM3
-
Rattus norvegicus
2.4.3.8 0.2
-
ganglioside GM3
-
Rattus norvegicus
2.4.3.9 0.08
-
lactosylceramide
-
Rattus norvegicus
2.4.3.9 1.5
-
CMP-N-acetyl-beta-neuraminate
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.3.2 Golgi apparatus
-
Rattus norvegicus 5794
-
2.4.3.2 membrane
-
Rattus norvegicus 16020
-
2.4.3.8 Golgi apparatus
-
Rattus norvegicus 5794
-
2.4.3.8 membrane
-
Rattus norvegicus 16020
-
2.4.3.9 Golgi apparatus
-
Rattus norvegicus 5794
-
2.4.3.9 membrane
-
Rattus norvegicus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.3.8 additional information no metal ion requirement Rattus norvegicus
2.4.3.9 additional information no metal ion requirement Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.2 Rattus norvegicus
-
female Wistar
-
2.4.3.8 Rattus norvegicus
-
female Wistar
-
2.4.3.9 Rattus norvegicus
-
female Wistar
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.2 liver
-
Rattus norvegicus
-
2.4.3.8 liver
-
Rattus norvegicus
-
2.4.3.9 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.2 CMP-N-acetyl-beta-neuraminate + ganglioside GM1a
-
Rattus norvegicus CMP + ganglioside GD1a i.e. ganglioside GD1a ?
2.4.3.8 CMP-alpha-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
Rattus norvegicus CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
?
2.4.3.8 CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
Rattus norvegicus CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide i.e. disialosyllactosylceramide or ganglioside GD3 ?
2.4.3.9 CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
Rattus norvegicus CMP + N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide i.e. ganglioside GM3 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.3.8 37
-
assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.3.2 6.4
-
-
Rattus norvegicus
2.4.3.8 5.8
-
-
Rattus norvegicus
2.4.3.9 5.7
-
-
Rattus norvegicus