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Literature summary extracted from

  • Morton, D.P.; Parsons, S.M.
    Biosynthetic direction substrate kinetics and product inhibition studies on the first enzyme of histidine biosynthesis, adenosine triphosphate phosphoribosyltransferase (1976), Arch. Biochem. Biophys., 175, 677-686.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.17 1-(5-phospho-alpha-D-ribosyl)-ATP product inhibition, competitive to both substrates Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 diphosphate non competitive to both substrates Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 L-histidine feed-back inhibition Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.17 Mg2+ magnesium could have an effect on the conformation of the enzyme and its activity which would be independent of the state of substrate complexation Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 additional information maximal activity is achieved when the concentration of free magnesium reaches about 2 mM, concentrations higher than 5 mM lead to inhibition perhaps due to the formation of MgATP2- complex Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate Salmonella enterica subsp. enterica serovar Typhimurium first step in histidine biosynthesis diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.17 Salmonella enterica subsp. enterica serovar Typhimurium
-
 LT2 strain TA2165
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.17
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.2.17 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate sequential kinetic mechanism in biosynthetic direction, ordered bi-bi mechanism with ATP binding first to free enzyme and phosphoribosyl-ATP dissociating last from enzyme-product complexes Salmonella enterica subsp. enterica serovar Typhimurium
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium 1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
 r
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate first step in histidine biosynthesis Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
 ?
2.4.2.17 additional information not: ribose 5-phosphate, AMP, ADP, UTP, CTP, GTP Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.17 25
-
 assay at Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.17 7.5
-
 assay at Salmonella enterica subsp. enterica serovar Typhimurium