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Literature summary extracted from

  • Morton, D.P.; Parsons, S.M.
    Inhibition of ATP phosphoribosyltransferase by AMP and ADP in the absence and presence of histidine (1977), Arch. Biochem. Biophys., 181, 643-648.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.17 ADP competitive to ATP, in the presence of histidine inhibition by AMP and ADP becomes positively cooperative and much more potent Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 AMP competitive inhibitor to 5-phospho-alpha-D-ribose 1-diphosphate, in the presence of histidine inhibition by AMP and ADP becomes positively cooperative and much more potent Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 L-histidine feed-back inhibition Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate Salmonella enterica subsp. enterica serovar Typhimurium first step in histidine biosynthesis diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.17 Salmonella enterica subsp. enterica serovar Typhimurium
-
 LT2 strain TA2165
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.17
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium 1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
 r
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate first step in histidine biosynthesis Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.17 25
-
 assay at Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.17 8.5
-
 assay at Salmonella enterica subsp. enterica serovar Typhimurium