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Literature summary extracted from

  • Brinkmann, T.; Weilke, C.; Kleesiek, K.
    Recognition of acceptor proteins by UDP-D-xylose proteoglycan core protein beta-D-xylosyltransferase (1997), J. Biol. Chem., 272, 11171-11175.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.26 0.0006
-
 bikunin recombinant mutant bikunin Homo sapiens
2.4.2.26 0.0009
-
 bikunin recombinant wild-type bikunin Homo sapiens
2.4.2.26 0.022
-
 QEEEGSGGGOK
-
 Homo sapiens
2.4.2.26 0.13
-
 NFDEIDRSGFGFN
-
 Homo sapiens
2.4.2.26 0.155
-
 cartilage chondroitin sulfate proteoglycan trifluoromethanesulfonic acid-degraded substrate Homo sapiens
2.4.2.26 0.19
-
 cartilage chondroitin sulfate proteoglycan hydrogen fluoride-degraded substrate Homo sapiens
2.4.2.26 0.39
-
 PLVSSGEDEPK
-
 Homo sapiens
2.4.2.26 0.42
-
 WAGGDASGE
-
 Homo sapiens
2.4.2.26 0.545
-
 silk fibroin
-
 Homo sapiens
2.4.2.26 0.94
-
 VCRSGSGLVGK
-
 Homo sapiens
2.4.2.26 2.67
-
 GVEGSADFLK
-
 Homo sapiens
2.4.2.26 3.625
-
 KTKGSGFFVF
-
 Homo sapiens
2.4.2.26 8.27
-
 KKDSGPY
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.26 extracellular in cell culture supernatant Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.26 UDP-alpha-D-xylose + [protein]-L-serine Homo sapiens initiation of chondroitin sulfate biosynthesis UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.26 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.26 partial Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.2.26 UDP-alpha-D-xylose + [protein]-L-serine = UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine chondroitin sulfate attachment site, determination of the consensus sequence for the recognition signal of the enzyme Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.26 cartilage sternal, from heart Homo sapiens
-
2.4.2.26 chondrocyte from heart sternal cartilage Homo sapiens
-
2.4.2.26 chondrocyte cell culture supernatant Homo sapiens
-
2.4.2.26 heart sternal cartilage Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.26 additional information very low activity with tripeptide SGG and peptide LNFSTGW Homo sapiens ?
-
 ?
2.4.2.26 UDP-alpha-D-xylose + [protein]-L-serine transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate Homo sapiens UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine
-
 ?
2.4.2.26 UDP-alpha-D-xylose + [protein]-L-serine transfers a beta-D-xylosyl residue to specific serine residues dependent on the consensus signal sequence Homo sapiens UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine
-
 ?
2.4.2.26 UDP-alpha-D-xylose + [protein]-L-serine initiation of chondroitin sulfate biosynthesis Homo sapiens UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine
-
 ?
2.4.2.26 UDP-D-xylose + bikunin recombinant wild-type from Chang liver hepatocytes and mutant, expressed in Escherichia coli Homo sapiens UDP + D-xylosyl-bikunin bound to serine residue ?
2.4.2.26 UDP-D-xylose + cartilage chondroitin sulfate proteoglycan degraded by hydrogen fluoride or trifluromethanesulfonic acid Homo sapiens UDP + cartilage chondroitin sulfate proteoglycan with xylosylserine
-
 ?
2.4.2.26 UDP-D-xylose + GVEGSADFLK derived from collagen X Homo sapiens UDP + GVEGS(-D-xylose)ADFLK
-
 ?
2.4.2.26 UDP-D-xylose + KKDSGPY
-
 Homo sapiens UDP + KKDS(-D-xylose)GPY
-
 ?
2.4.2.26 UDP-D-xylose + KTKGSGFFVF
-
 Homo sapiens UDP + KTKGS(-D-xylose)GFFVF
-
 ?
2.4.2.26 UDP-D-xylose + NFDEIDRSGFGFN
-
 Homo sapiens UDP + NFDEIDRS(-D-xylose)GFGFN
-
 ?
2.4.2.26 UDP-D-xylose + PLVSSGEDEPK derived from neurocan protein Homo sapiens UDP + ? D-xylose bound to a serine residue ?
2.4.2.26 UDP-D-xylose + QEEEGSGGGOK best substrate Homo sapiens UDP + QEEEGS(-D-xylose)GGGOK
-
 ?
2.4.2.26 UDP-D-xylose + QEEEGSGGGOK peptide derived from bikunin Homo sapiens UDP + QEEEGS(-D-xylose)GGGOK
-
 ?
2.4.2.26 UDP-D-xylose + silk fibroin acceptor substrate contains repetitive sequence Gly-Ser-Gly-Ala-Gly-Ala Homo sapiens UDP + silk fibroin with xylosylserine
-
 ?
2.4.2.26 UDP-D-xylose + VCRSGSGLVGK derived from apolipoprotein J Homo sapiens UDP + VCRSGSGLVGK D-xylose bound to a serine residue ?
2.4.2.26 UDP-D-xylose + WAGGDASGE
-
 Homo sapiens UDP + WAGGDAS(-D-xylose)GE
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.26 XT
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.26 34
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.26 6.5
-
 assay at Homo sapiens